CALERIE (Tufts) - Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy

Completed · Phase 1

Conditions studied: Aging

In brief

This study is one of three CALERIE trials that test the hypothesis that a reduced calorie, nutritionally sound diet increases the length of life and prevents some age-related chronic diseases such as cancer, diabetes, and cardiovascular disease. The three sites that are participating in the CALERIE trial represent a diversity of subject populations and interventional strategies.

Key facts

Study ID

NCT00099099

Run by

National Institute on Aging (NIA)

People needed

44

Starts

2002-03-01

Expected to finish

2004-12-01

Last updated by the study team

2009-12-11

Who can join

Age: 25 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy men and women
• Body mass index (BMI) = 25-30
• Slightly overweight, < 275 lbs
• Women 25-45, pre-menopause
• Men 25-50
• Not traveling often or planning to move
• Exclusions:
• Cardiovascular disease or blood pressure greater than 160/90
• Diabetes
• Major psychiatric disorders
• Eating disorders
• Post obese; previous BMI > 32
• Weight change of more than ten pounds in the past 90 days
• Over 275 pounds
• Smoking
• Regular exercise, more than twice per week
• Current prescription drug use, except oral contraceptives
• Alcoholism or substance abuse
• Pregnant or lactating (breast feeding), planning to become pregnant, or not regularly using contraception
• Abnormal electrocardiogram (EKG)
• Local resident for less than one year
• Occupations requiring full alertness and motor skills, with no allowance for a chance of postural dizziness (airline pilots, etc.)
• Injuries by any metallic object that is still present in the body
• Braces, non-removable dentures, or non-removable bridgework

Where it is running

• Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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