Evaluation of the Safety and Efficacy of Memantine as Adjunctive Treatment in Schizophrenia Patients
Completed · Phase 2
Conditions studied: Schizophrenia
In brief
Standard antipsychotic drug regimens do not fully address the impact of cognitive symptoms associated with schizophrenia. The NMDA receptor has been connected to the pathophysiology of schizophrenia. Memantine is an uncompetitive NMDA receptor antagonist. It is hypothesized that adjunctive therapy with memantine will reduce NMDA receptor hyperactivity, improving signal to noise ratio and thereby improving cognitive symptoms.
Key facts
- Study ID
- NCT00097942
- Run by
- Forest Laboratories
- People needed
- 138
- Starts
- 2004-08-01
- Expected to finish
- 2005-09-01
- Last updated by the study team
- 2012-03-05
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- DSM-IV diagnosed Schizophrenia or schizoaffective disorder who are on a stable antipsychotic regimen with Brief Psychiatric Rating Scale (BPRS) total score greater than or equal to 26 and greater than or equal to 4 on at least one item
You may not qualify if…
- Secondary diagnosis of Bipolar I disorder
- Suicidal history
- Organic brain disease
- Dementia
- History of substance abuse
Where it is running
- Synergy Clinical Research — National City, California, United States
- VA San Diego Healthcare System — San Diego, California, United States
- University of Miami Jackson Memorial Hospital — Miami, Florida, United States
- University of Iowa Psychiatric Research — Iowa City, Iowa, United States
- CBH Health, LLC — Rockville, Maryland, United States
- Metropolitan Psychiatric Center — St Louis, Missouri, United States
- Dartmouth Hitchcock Medical School — Lebanon, New Hampshire, United States
- Nathan Kline Institute — Orangeburg, New York, United States
- Duke University John Umstead Hospital — Butner, North Carolina, United States
- UNC - Chapel Hill, Clinical Research Unit — Raleigh, North Carolina, United States
- University of Cincinnati Medical Science Building — Cincinnati, Ohio, United States
- University Hills Clinical Research — Irving, Texas, United States
- Medication Research Clinic — San Antonio, Texas, United States
Full record on ClinicalTrials.gov
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