Efficacy and Safety of Aricept in the Treatment of Severe Alzheimer's Disease

Completed · Phase 3

Conditions studied: Alzheimer's Disease, Dementia

In brief

Donepezil hydrochloride (Aricept) has been approved to treat symptoms associated with mild to moderate Alzheimer's disease (AD). Aricept has been shown to improve the memory and thinking abilities, activities of daily living and global function in patients. The purpose of the study is to further investigate the effectiveness and safety of donepezil in patients with severe Alzheimer's disease. Donepezil is thought to work in the brain by increasing the levels of an important brain chemical called acetylcholine. This chemical helps a person's memory to work better.

Key facts

Study ID

NCT00096473

Run by

Eisai Inc.

People needed

229

Starts

2001-01-01

Expected to finish

2005-09-01

Last updated by the study team

2011-04-01

Who can join

Age: 50 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Clinically diagnosed Alzheimer's Disease with MMSE score 1\~12
• Have not been treated by any medication for Alzheimer's Disease in past 3 months
• Live in community or Assisted Living Facility
• Healthy or with chronic diseases that are medically controlled or stabilized
• Able to swallow tablets

You may not qualify if…

• Any primary neurological or psychiatric diagnosis (including depressive disorder) other than Alzheimer's Disease
• Dementia caused by organic diseases other than Alzheimer's Disease

Where it is running

• Study site — Northport, Alabama, United States
• Study site — Phoenix, Arizona, United States
• Study site — Sun City, Arizona, United States
• Study site — Tucson, Arizona, United States
• Study site — San Francisco, California, United States
• Study site — Santa Monica, California, United States
• Study site — Torrance, California, United States
• Study site — Denver, Colorado, United States
• Study site — Fort Lauderdale, Florida, United States
• Study site — Fort Myers, Florida, United States
• Study site — North Miami, Florida, United States
• Study site — St. Petersburg, Florida, United States
• Study site — Atlanta, Georgia, United States
• Study site — Chicago, Illinois, United States
• Study site — New Orleans, Louisiana, United States
• Study site — Springfield, Massachusetts, United States
• Study site — Long Branch, New Jersey, United States
• Study site — Piscataway, New Jersey, United States
• Study site — New Hyde Park, New York, United States
• Study site — Greenville, North Carolina, United States
• Study site — Raleigh, North Carolina, United States
• Study site — Centerville, Ohio, United States
• Study site — Oklahoma City, Oklahoma, United States
• Study site — Medford, Oregon, United States
• Study site — Portland, Oregon, United States

Full record on ClinicalTrials.gov

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