Combination Chemotherapy and Radiation in Treating Patients With Stage III or IV Head and Neck Cancer (Paradigm Trial)
Completed · Phase 3
Conditions studied: Head and Neck Cancer
In brief
RATIONALE: Drugs used in chemotherapy, such as docetaxel, cisplatin, fluorouracil, and carboplatin, work in different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining chemotherapy with radiation therapy may kill more tumor cells. It is not yet known which regimen of chemotherapy and radiation therapy is most effective in treating head and neck cancer. PURPOSE: Randomized phase III trial to compare the effectiveness of two different regimens of chemotherapy and radiation therapy in treating patients who have stage III or stage IV head and neck cancer.
Key facts
- Study ID
- NCT00095875
- Run by
- Dana-Farber Cancer Institute
- People needed
- 145
- Starts
- 2004-08-01
- Expected to finish
- 2012-04-01
- Last updated by the study team
- 2013-11-19
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Rebecca and John Moores UCSD Cancer Center — La Jolla, California, United States
- CCOP - Colorado Cancer Research Program — Denver, Colorado, United States
- Eugene M. and Christine E. Lynn Cancer Institute at Boca Raton Community Hospital - Main Campus — Boca Raton, Florida, United States
- Winship Cancer Institute of Emory University — Atlanta, Georgia, United States
- Cardinal Bernardin Cancer Center at Loyola University Medical Center — Maywood, Illinois, United States
- Maine Center for Cancer Medicine and Blood Disorders - Scarborough — Scarborough, Maine, United States
- Greenebaum Cancer Center at University of Maryland Medical Center — Baltimore, Maryland, United States
- Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute — Boston, Massachusetts, United States
- Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis — St Louis, Missouri, United States
- Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center — Lebanon, New Hampshire, United States
- UMDNJ University Hospital — Newark, New Jersey, United States
- Albert Einstein Cancer Center at Albert Einstein College of Medicine — The Bronx, New York, United States
- Blumenthal Cancer Center at Carolinas Medical Center — Charlotte, North Carolina, United States
- UPMC Cancer Centers — Pittsburgh, Pennsylvania, United States
- Klinikum der J.W. Goethe Universitaet — Frankfurt, Germany
Full record on ClinicalTrials.gov
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