Irbesartan Versus Placebo in Combination With Ramipril for Treatment of Albuminuria

Completed · Phase 4 · Has a placebo group

Conditions studied: Albuminuria

In brief

Albumin in the urine is usually a signal that you might be at risk of cardiovascular complications. The purpose of this study is to determine if the albumin in your urine can be decreased by the treatment regimen that consists of irbesartan taken at the same time with ramipril.

Key facts

Study ID

NCT00095290

Run by

Bristol-Myers Squibb

People needed

400

Starts

2004-09-01

Expected to finish

2005-11-01

Last updated by the study team

2011-04-15

Who can join

Age: 55 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subjects must be willing and able to provide written informed consent.
• Males and Females 55 years of age and over
• Subjects must have a history of high blood pressure and elevated cardiovascular risk defined as one of the following:
• Diabetes
• Advanced coronary disease defined as previous myocardial infarction. Active angina, or significant changes in tests indicating ischemia
• Artery disease in the legs, limiting walking capacity and/or blood flow in the legs
• Stroke occurring more than 3 months prior to the screening visit
• All subjects must also have albuminuria (protein in the urine) that is confirmed by a urine test at the first study visit.
• All subjects must currently be treated with a class of drugs called ACE inhibitors (e.g., benazepril, captopril, enalapril, lisinopril, moexipril, ramipril, quinapril, perindopril) for at least 2 months prior to the study.
• Women of childbearing potential (WOCBP) must be using adequate methods of contraception to avoid pregnancy throughout the study and four weeks after the study ends.

You may not qualify if…

• Women who are pregnant or breastfeeding.
• Acute systemic febrile/infectious disease or infectious or inflammatory disease of the kidneys
• Narrowing of the kidney arteries
• Hypotension (low blood pressure) or very high blood pressure
• Moderate or Severe Heart Failure
• Chronic autoimmune disease
• Cancer unless cured or no further treatment needed
• Severe kidney failure
• Allergy to drugs used in the study: ARBs (candesartan, irbesartan, losartan, telmisartan, valsartan, and/or any other ARB currently or previously in development) and ACE-inhibitors (benazepril, captopril, enalapril, lisinopril, moexipril, ramipril, quinapril, perindopril)
• Administration of any other investigational drug within 30 days of planned enrollment into the study.
• Any circumstances that would prevent coming for study visits or taking study drugs

Where it is running

• Local Institution — Miami, Florida, United States
• Local Institution — West Palm Beach, Florida, United States
• Local Institution — Chicago, Illinois, United States
• Local Institution — Flushing, New York, United States
• Local Institution — New York, New York, United States
• Local Institution — Cleveland, Ohio, United States
• Local Institution — Philadelphia, Pennsylvania, United States
• Local Institution — Providence, Rhode Island, United States
• Local Institution — San Antonio, Texas, United States
• Local Institution — Milwaukee, Wisconsin, United States
• Local Institution — Burwood, New South Wales, Australia
• Local Institution — Camperdown, New South Wales, Australia
• Local Institution — Gosford, New South Wales, Australia
• Local Institution — St Leonards, New South Wales, Australia
• Local Institution — Woolloongabba, Queensland, Australia
• Local Institution — Box Hill, Victoria, Australia
• Local Institution — Fitzroy, Victoria, Australia
• Local Institution — Parkville, Victoria, Australia
• Local Institution — Fremantle, Western Australia, Australia
• Local Institution — Edmonton, Alberta, Canada
• Local Institution — Vancouver, British Columbia, Canada
• Local Institution — Winnipeg, Manitoba, Canada
• Local Institution — Halifax, Nova Scotia, Canada
• Local Institution — Scarborough Village, Ontario, Canada
• Local Institution — Tustin, California, United States

Full record on ClinicalTrials.gov

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