Predictors of Cognitive Decline in Normal Aging

Status unconfirmed

Conditions studied: Alzheimer Disease, Dementia

In brief

The goal of this project is to develop an early diagnostic test for Alzheimer's disease (AD) by monitoring loss of neurons and brain size reductions over a period of five years.

Key facts

Study ID

NCT00094939

Run by

National Institute on Aging (NIA)

People needed

170

Starts

2003-09-01

Expected to finish

2008-08-01

Last updated by the study team

2009-12-14

Who can join

Age: 60 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Males and females, from all racial and ethnic categories between the ages of 60-80 years of age, with English as their first language.
• Residents of the New York City metropolitan area.
• Minimum of 12 years of education.
• Participants will be grouped according to the following classifications: normal aging, mild cognitive impairment (MCI), Alzheimer's disease (AD), or frontotemporal dementia (FTD).
• Participants will agree to ApoE genotyping and DNA banking.

You may not qualify if…

• Past history or MRI evidence of brain damage including significant trauma, stroke, hydrocephalus, lacunar infarcts, seizures, mental retardation or serious neurological disorder.
• Significant history of alcoholism or drug abuse.
• History of psychiatric illness (e.g., schizophrenia, mania or depression).
• Any focal signs or significant neuropathology.
• A score of 4 or greater on the Modified Hachinski Ischemia Scale suggesting cerebrovascular disease.
• A total score of 16 or more on the Hamilton Depression Scale to exclude possible cases of primary depression.
• Evidence of clinically relevant and uncontrolled hypertensive, cardiac, pulmonary, vascular, metabolic or hematologic conditions.
• Physical impairment of such severity as to adversely affect the validity of psychological testing.
• Hostility or refusal to cooperate.
• Any prosthetic devices (e.g., pacemaker or surgical clips) that could be affected by the magnetic field employed during MRI imaging.
• History of familial early onset dementia.

Where it is running

• Center for Brain Health, Silberstein Institute, New York University School of Medicine — New York, New York, United States (enrolling)

Full record on ClinicalTrials.gov

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