PET Changes in Alzheimer's Disease (AD)

Status unconfirmed

Conditions studied: Alzheimer Disease

In brief

The purpose of this study is to identify the earliest predictors of memory and brain deterioration in pre-clinical Alzheimer's disease using positron emission tomography (PET) to monitor brain glucose metabolism.

Key facts

Study ID

NCT00094913

Run by

National Institute on Aging (NIA)

People needed

105

Starts

2004-05-01

Expected to finish

2005-04-01

Last updated by the study team

2009-05-27

Who can join

Age: 20 and older, up to 90. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Males and females with a minimum high school education and between the ages of 50 and 90 will be selected for Groups 1 and 2. For Group 3, normal subjects between the ages of 20 and 49 years of age will be selected. The Groups 1 and 2 will be balanced for age, and all three groups balanced for gender and ApoE genotype.
• Discontinuance of all psychotropic and/or cognitively active medication at least four weeks prior to evaluation.

You may not qualify if…

• Past history or MRI evidence of brain damage including significant trauma, stroke, hydrocephalus, lacunar infarcts, seizures, mental retardation or serious neurological disorder.
• Significant history of alcoholism or drug abuse.
• Any history of psychiatric illness (e.g., schizophrenia, mania or depression).
• Any focal signs or significant neuropathology.
• A score of 4 or greater on the Modified Hachinski Ischemia Scale, indicative of cerebrovascular disease.
• A total score of 16 or more on the Hamilton Depression Scale to exclude possible cases of primary depression.
• Evidence of clinically relevant hypertensive, cardiac, pulmonary, vascular, metabolic or hematologic conditions. Specific exclusion will be made for individuals with fasting glucose levels >110 mg/dl.
• Physical impairment of such severity as to adversely affect the validity of psychological testing.
• Hostility or refusal to cooperate.
• Any prosthetic devices (e.g., pacemaker or surgical clips) that could be affected by the magnetic field employed during MRI imaging.
• Evidence of cognitive or memory impairment reaching early AD levels at the initial evaluation. At baseline, delayed paragraph recall z-scores > 2 below the reference group.

Where it is running

• Center for Brain Health, Silberstein Institute, New York University — New York, New York, United States

Full record on ClinicalTrials.gov

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