Effectiveness of Depression Treatment Following Coronary Artery Bypass Surgery

Completed · Not applicable

Conditions studied: Cardiovascular Diseases, Coronary Disease, Heart Diseases, Depression

In brief

The purpose of this study is to treat depression in patients who have undergone coronary artery bypass graft (CABG).

Key facts

Study ID

NCT00091962

Run by

University of Pittsburgh

People needed

453

Starts

2003-08-01

Expected to finish

2009-12-01

Last updated by the study team

2016-04-14

Who can join

Age: 18 and older, up to 100. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Recently underwent CABG (combined or redo procedure) at one of 8 Pittsburgh area study hospitals
• A PHQ score greater than 10 OR if nondepressed control, a PHQ score less than 5 at both 2 days post CABG to the date of discharge following CABG and when reassessed 2 weeks after hospital discharge
• Folstein Mini-Mental State Examination (MMSE) score greater than or equal to 24
• Able to be evaluated and treated for depression as an outpatient post CABG
• Has a household telephone

You may not qualify if…

• Presently in treatment with a mental health specialist
• Actively suicidal
• History of psychotic illness
• History of bipolar illness according to subject self-report and past medical history
• Current alcohol dependence or other substance abuse as evidenced by chart review and the CAGE questionnaire
• Organic mood syndromes, including those secondary to medical illness or drugs
• Presence of non-cardiovascular conditions that are likely to be fatal within 1 year
• Unstable medical condition as indicated by history, physical, and/or laboratory findings
• Previous enrollment in the study cohort
• Non-English speaking, illiterate, or possessing any other communication barrier
• If nondepressed control, current or previous diagnosis or treatment of depression

Where it is running

• University of Pittsburgh School of Medicine — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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