Pexelizumab in Conjunction With Angioplasty in Acute Myocardial Infarction (APEX-AMI)
Completed · Phase 3 · Has a placebo group
Conditions studied: Acute Myocardial Infarction
In brief
In the setting of reperfusion therapy in an acute myocardial infarction using primary percutaneous intervention (PCI), the body's own inflammatory system involving the complement cascade may be harmful. This study will test the safety and efficacy of a novel complement inhibitor, pexelizumab to reduce mortality at 30 days.
Key facts
- Study ID
- NCT00091637
- Run by
- Procter and Gamble
- People needed
- 5745
- Starts
- 2004-04-01
- Expected to finish
- 2007-05-01
- Last updated by the study team
- 2023-11-18
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Cardiac symptoms for at least 20 minutes within past 6 hours;
- Will undergo primary PCI;
- Has ECG evidence of acute high risk ST elevation myocardial infarction;
- Willing and able to be followed for at least 12 months.
You may not qualify if…
- Isolated low risk inferior wall myocardial infarction;
- Received fibrinolytic therapy;
- History of complement deficiency;
- Suspected neisserial infection;
- Participating in other investigational study;
- Pregnancy;
- Previous enrollment.
Where it is running
- Mayo Clinic Hospital — Phoenix, Arizona, United States
- North Phoenix Heart Center — Phoenix, Arizona, United States
- Northwest Medical Center — Tucson, Arizona, United States
- Sparks Regional Medical Center — Fort Smith, Arkansas, United States
- Arkansas State Hospital — Little Rock, Arkansas, United States
- Brotman Medical Center — Beverly Hills, California, United States
- Providence Saint Joseph Medical Center — Burbank, California, United States
- Palomar Medical Center — Escondido, California, United States
- Los Angeles Community Hospital — Los Angeles, California, United States
- Memorial Medical Center — Modesto, California, United States
- Sutter Memorial Hospital — Sacramento, California, United States
- University of CA, San Diego Medical — San Diego, California, United States
- Sutter Medical Center of Santa Rosa — Santa Rosa, California, United States
- Providence Holy Cross Medical Center — Valencia, California, United States
- University of Colorado Hospital — Denver, Colorado, United States
- St. Vincent Medical Center — Bridgeport, Connecticut, United States
- University of Connecticut Health Center — Farmington, Connecticut, United States
- Yale - New Haven — New Haven, Connecticut, United States
- George Washington University Hospital — Washington D.C., District of Columbia, United States
- JFK Medical Center — Atlantis, Florida, United States
- Morton Plant Hospital — Clearwater, Florida, United States
- North Ridge Medical Center — Fort Lauderdale, Florida, United States
- St. Luke's Hospital — Jacksonville, Florida, United States
- Health First Holmes Regional Medical Center — Melbourne, Florida, United States
- Huntsville Hospital — Huntsville, Alabama, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.