IMMEDIATE Trial - Out of Hospital Administration of Glucose, Insulin and Potassium.

Completed · Phase 3 · Has a placebo group

Conditions studied: Angina, Unstable, Cardiovascular Diseases, Heart Diseases, Coronary Disease, Myocardial Infarction, Heart Failure, Congestive

In brief

The purpose of this study is to test the impact of pharmacological myocardial metabolic support, in the form of intravenous (IV) glucose, insulin and potassium (GIK), for the treatment of patients with threatened or established acute myocardial infarction (AMI).

Key facts

Study ID

NCT00091507

Run by

Tufts Medical Center

People needed

911

Starts

2006-11-01

Expected to finish

2012-08-01

Last updated by the study team

2016-03-02

Who can join

Age: 30 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Symptoms of threatened or established AMI including but not limited to:
• Chest pain, discomfort, or tightness
• Arm or shoulder pain
• Jaw pain
• Epigastric discomfort
• Shortness of breath
• 12-lead electrocardiogram (ECG) with two or more contiguous leads with ST elevation greater than 1 mm, ST depression greater than 0.5 mm, T wave inversion or other T wave abnormalities (hyperacute T waves), or left bundle branch block (not known to be old). Identification aided by the acute cardiac ischemia time-insensitive predictive instrument (ACI-TIPI)and thrombolytic predictive instrument (TPI) decision support software (ACI-TIPI >= 75% and TPI detection of suspected STEMI).

You may not qualify if…

• End-stage kidney failure requiring dialysis
• Rales present more than halfway up the back
• Unable to comply with the requirements of the study
• Incarcerated
• Known to be pregnant

Where it is running

• Anchorage Site — Anchorage, Alaska, United States
• New Haven Site — New Haven, Connecticut, United States
• Macon Site — Macon, Georgia, United States
• Brockton Site — Brockton, Massachusetts, United States
• Concord Site — Concord, Massachusetts, United States
• St. Paul Site — Saint Paul, Minnesota, United States
• Albuquerque Site — Albuquerque, New Mexico, United States
• Hershey Site — Hershey, Pennsylvania, United States
• Sioux Falls Site — Sioux Falls, South Dakota, United States
• Dallas Site — Dallas, Texas, United States
• El Paso Site — El Paso, Texas, United States
• Bellingham Site — Bellingham, Washington, United States
• Milwaukee Site — Milwaukee, Wisconsin, United States

Full record on ClinicalTrials.gov

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