Nicotine Treatment of Mild Cognitive Impairment (MCI)

Status unconfirmed · Phase 1 · Has a placebo group

Conditions studied: Age-Related Memory Disorders

In brief

The purpose of this 12-month study is to determine whether nicotine, administered in the form of nicotine patches, can improve symptoms of memory loss in some people experiencing mild memory problems (referred to in this study as "mild cognitive impairment" or MCI).

Key facts

Study ID

NCT00091468

Run by

National Institute on Aging (NIA)

People needed

75

Starts

2003-09-01

Expected to finish

2008-07-01

Last updated by the study team

2008-01-15

Who can join

Age: 55 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may not qualify if…

• Any significant neurologic disease such as Alzheimer's disease, Parkinson's disease, multi-infarct dementia, Huntington's disease, normal pressure hydrocephalus, brain tumor, progressive supranuclear palsy, seizure disorder, subdural hematoma, multiple sclerosis, or history of significant head trauma followed by persistent neurologic deficits or known structural brain abnormalities.
• Major depression or another major psychiatric disorder as described in DSM-IV within the past 2 years.
• History of alcohol or substance abuse or dependence within the past 2 years (DSM IV criteria).
• Any significant, unstable medical condition.
• Use of any investigational drugs within 30 days or 5 half-lives, whichever is longer, prior to screening.
• Any tobacco use within the past year.
• Exceptions to these specific Inclusion and Exclusion Criteria (e.g., WMS-R cutoffs) may be made on a case by case basis by the Principal Investigator.

Where it is running

• Georgetown University Medical Center, Department of Neurology — Washington D.C., District of Columbia, United States
• Duke University, Duke Health Center at Morreene Road — Durham, North Carolina, United States
• University of Vermont College of Medicine — Burlington, Vermont, United States

Full record on ClinicalTrials.gov

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