Chemotherapy for Patients With Advanced Solid Tumors or Non-Hodgkin's Lymphoma
Status unconfirmed · Phase 1
Conditions studied: Solid Malignancies, Non-Hodgkin's Lymphoma
In brief
The purposes of this study are to determine: * the largest dose of AQ4N that can be safely given once a week for three weeks out of a 4 week cycle * the side effects of AQ4N when given on the above schedule * how much AQ4N is in the blood and urine at specific times after administration and how the body get rids of AQ4N * if AQ4N helps treat cancer
Key facts
- Study ID
- NCT00090727
- Run by
- Novacea
- People needed
- 45
- Starts
- 2004-08-01
- Last updated by the study team
- 2006-11-02
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Advanced solid malignancy or non-Hodgkin's lymphoma that is refractory to treatment or has recurred
- Age > 18 years
- Adequate hematologic (blood), kidney and liver function
- Negative pregnancy test (females of childbearing potential only)
- Willingness to use effective contraception by both males and females throughout the treatment period and for at least 2 months following treatment.
You may not qualify if…
- Any chemotherapy or radiation within the past 4 weeks
- Symptomatic or uncontrolled brain metastases (patients with history of brain metastases who have had repeat brain scans within the past 30 days that demonstrate no evidence of tumor progression or brain swelling and who do not require corticosteriod treatment may be eligible)
- Significant cardiovascular illness including, but not limited to, the following: active infection, uncontrolled hypertension, symptomatic congestive heart failure, unstable angina pectoris, heart attack within the past six months, or uncontrolled, irregular heart beat
- Inadequate cardiac function
- Prior investigational therapy within the past 28 days
- Pregnant or breast feeding women
Where it is running
- Weiler Hospital of Albert Einstein College of Medicine — The Bronx, New York, United States
- Cancer Therapy & Research Center / Institute for Drug Development — San Antonio, Texas, United States
Full record on ClinicalTrials.gov
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