To Find the Best Dose of pVGI.1(VEGF2) to Benefit Angina Patients When Given With an Experimental Injection Catheter

Status unconfirmed · Phase 2

Conditions studied: Angina Pectoris

In brief

The purpose of this study is to determine the optimum effective dose of recombinant plasmid DNA \[pVGI.1(VEGF2)\] gene therapy administered using an experimental cardiac direct injection catheter (Stiletto™) system needed to benefit patients with severe Angina Pectoris.

Key facts

Study ID

NCT00090714

Run by

Corautus Genetics

People needed

404

Starts

2004-08-01

Last updated by the study team

2006-04-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Are willing and able to give informed consent
• Have CCS class III or IV angina refractory to optimized medical therapy
• Experience signs or symptoms of angina during the exercise tolerance test (ETT)
• Have identified area(s) of reversible ischemic myocardium
• Have procedurally acceptable targeted treatment zones

You may not qualify if…

• Have exercise-limited non-cardiac chest discomfort
• Unwilling or unable to undergo exercise testing
• Able to exercise greater than 6 minutes on the treadmill
• Are candidates for conventional revascularization procedures
• Are or have been enrolled within 30 days, in another experimental study
• Have had the most recent angiogram more than 6 Months prior to screening
• Previously received an investigational angiogenic agent
• Have another disease severe enough to limit exercise test or place patient at risk
• Have uncontrolled: atrial fibrillation, atrial flutter, and/or significant arrhythmias
• Have evidence of left ventricular aneurysm or ventricular thrombus
• Are unwilling or unable to undergo cardiac catheterization or nuclear testing procedures
• Have had a Q-wave MI, within 60 days
• Have severe aortic valve stenosis or have a mechanical aortic or mitral valve
• Have unstable angina or an acute non-Q-wave myocardial infarction within 14 days
• Have had a documented stroke or transient ischemic attack within 60 days
• Are pacemaker dependent
• Have a recent history of active diabetic retinopathy or age-related wet macular degeneration
• Have a history of cancer within the last 5 yrs. or have current evidence of a malignant neoplasm
• Have a history of alcohol or drug abuse within 90 days
• Are pregnant or lactating
• Have reproductive potential and are unwilling to use condoms for contraception for 1 year after treatment - both male and female
• Are unable to return to the clinic for the scheduled follow-up appointments
• Are taking medications which may produce an undue risk
• Have areas of LV wall less than 6mm thick

Where it is running

• Cardiology, P.C. — Birmingham, Alabama, United States
• Arizona Heart Institute — Phoenix, Arizona, United States
• Mayo Clinic Hospital/Scottsdale — Phoenix, Arizona, United States
• Scripps Green Medical Center — La Jolla, California, United States
• Aurora Denver Cardiology Associates — Aurora, Colorado, United States
• Washington Heart — Washington D.C., District of Columbia, United States
• Shands Hospital - Jacksonville, FL — Jacksonville, Florida, United States
• Crawford Long Hospital — Atlanta, Georgia, United States
• Fuqua Heart Center of Piedmont Hospital — Atlanta, Georgia, United States
• St. Joseph Hospital of Atlanta — Atlanta, Georgia, United States
• Rush University Medical Center — Chicago, Illinois, United States
• Evanston Northwestern Healthcare — Evanston, Illinois, United States
• Midwest Heart Foundation — Lombard, Illinois, United States
• Prairie Cardiovascular — Springfield, Illinois, United States
• The Care Group, LLC — Indianapolis, Indiana, United States
• Midwest CV Research Foundation — Davenport, Iowa, United States
• Medstar Research — Towson, Maryland, United States
• Caritas St. Elizabeth's Medical Center — Boston, Massachusetts, United States
• Borgess Research Institute — Kalamazoo, Michigan, United States
• Minneapolis Heart Institute — Minneapolis, Minnesota, United States
• Mayo Clinic Hospital/Rochester — Rochester, Minnesota, United States
• Nebraska Heart Institute — Lincoln, Nebraska, United States
• New York Presbyterian Hospital — New York, New York, United States
• Columbia Presbyterian — New York, New York, United States
• University of Rochester — Rochester, New York, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.