SU011248 In The Treatment Of Patients With Bevacizumab (Avastin)-Refractory Metastatic Renal Cell Carcinoma

Completed · Phase 2

Conditions studied: Carcinoma, Renal Cell

In brief

The purpose of this study is to test whether sunitinib (SU011248) has activity and is safe in patients with renal cell carcinoma (RCC) who have failed prior therapy with bevacizumab (Avastin) -based treatment.

Key facts

Study ID

NCT00089648

Run by

Pfizer

People needed

61

Starts

2004-12-01

Expected to finish

2008-03-01

Last updated by the study team

2010-01-12

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Histologically proven renal cell carcinoma of clear cell histology with metastases
• Evidence of measurable disease
• Radiographic evidence of disease progression during or within 3 months of completion of bevacizumab-based treatment
• Prior radical or partial nephrectomy

You may not qualify if…

• Prior treatment with any other anti-angiogenic therapy other than bevacizumab
• Prior systemic treatment for RCC > 2 regimens
• History of or known brain metastases
• Serious acute or chronic illness or recent history of significant cardiac abnormality

Where it is running

• Pfizer Investigational Site — Duarte, California, United States
• Pfizer Investigational Site — Pasadena, California, United States
• Pfizer Investigational Site — San Francisco, California, United States
• Pfizer Investigational Site — Chicago, Illinois, United States
• Pfizer Investigational Site — Boston, Massachusetts, United States
• Pfizer Investigational Site — Boston, Massachusetts, United States
• Pfizer Investigational Site — Boston, Massachusetts, United States
• Pfizer Investigational Site — Durham, North Carolina, United States
• Pfizer Investigational Site — Cleveland, Ohio, United States
• Pfizer Investigational Site — Nashville, Tennessee, United States
• Pfizer Investigational Site — Dallas, Texas, United States

Full record on ClinicalTrials.gov

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