Vaccine Therapy and Sargramostim Compared With Placebo and Sargramostim Following Rituximab in Treating Patients With Non-Hodgkin's Lymphoma

Stopped early · Phase 3

Conditions studied: Lymphoma

In brief

RATIONALE: Monoclonal antibodies such as rituximab can locate cancer cells and either kill them or deliver cancer-killing substances to them without harming normal cells. Vaccines made from a person's cancer cells may make the body build an immune response to kill cancer cells. Colony-stimulating factors such as GM-CSF increase the number of immune cells found in bone marrow and peripheral blood. It is not yet known whether combining rituximab and GM-CSF with vaccine therapy may cause a stronger immune response and kill more cancer cells. PURPOSE: This randomized phase III trial is studying giving rituximab and GM-CSF together with vaccine therapy and comparing it to giving rituximab and GM-CSF alone in treating patients with newly diagnosed, relapsed, or refractory B-cell non-Hodgkin's lymphoma.

Key facts

Study ID

NCT00089115

Run by

Favrille

Starts

2004-07-01

Last updated by the study team

2013-08-02

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Mayo Clinic Scottsdale — Scottsdale, Arizona, United States
• Tower Cancer Research Foundation — Beverly Hills, California, United States
• Rebecca and John Moores UCSD Cancer Center — La Jolla, California, United States
• Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center — Los Angeles, California, United States
• USC/Norris Comprehensive Cancer Center and Hospital — Los Angeles, California, United States
• Hoag Cancer Center at Hoag Memorial Hospital Presbyterian — Newport Beach, California, United States
• Kaiser Permanente Medical Center - Kaiser Foundation Hospital - San Diego — San Diego, California, United States
• Sharp Memorial Hospital Cancer Center — San Diego, California, United States
• UCSF Comprehensive Cancer Center — San Francisco, California, United States
• Stanford Cancer Center at Stanford University Medical Center — Stanford, California, United States
• Kaiser Permanente Medical Center - Vallejo — Vallejo, California, United States
• Rocky Mountain Cancer Centers - Denver Midtown — Denver, Colorado, United States
• Medical Oncology Hematology Consultants, P.A. at Helen F. Graham Cancer Center — Newark, Delaware, United States
• Lombardi Cancer Center at Georgetown University Medical Center — Washington D.C., District of Columbia, United States
• Center for Hematology-Oncology - Boca Raton — Boca Raton, Florida, United States
• University of Florida Health Science Center - Jacksonville — Jacksonville, Florida, United States
• H. Lee Moffitt Cancer Center and Research Institute at University of South Florida — Tampa, Florida, United States
• North Idaho Cancer Center — Coeur d'Alene, Idaho, United States
• Robert H. Lurie Comprehensive Cancer Center at Northwestern University — Chicago, Illinois, United States
• Rush University Medical Center — Chicago, Illinois, United States
• Indiana University Cancer Center — Indianapolis, Indiana, United States
• Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center — Kansas City, Kansas, United States
• Markey Cancer Center at University of Kentucky Chandler Medical Center — Lexington, Kentucky, United States
• Ochsner Cancer Institute at Ochsner Clinic Foundation — New Orleans, Louisiana, United States
• Comprehensive Cancer Center at University of Alabama at Birmingham — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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