Carboplatin, Paclitaxel and TLK286 (Telcyta) as First-Line Therapy in Advanced Non-Small Cell Lung Cancer

Completed · Phase 1/Phase 2

Conditions studied: Carcinoma, Non-Small-Cell Lung

In brief

The purpose of this trial is to study the efficacy and safety of the triplet combination of TLK286, carboplatin and paclitaxel as first-line therapy for patients with advanced non-small cell lung cancer.

Key facts

Study ID

NCT00088556

Run by

Telik

People needed

100

Starts

2004-08-01

Expected to finish

2009-05-01

Last updated by the study team

2012-05-31

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18 years of age or older
• Histologically confirmed non-small cell lung cancer (NSCLC)
• Stage IV or IIIB (disease that is not eligible for combined modality chemotherapy and radiation)
• Measurable disease by RECIST
• ECOG status of 0-1
• Adequate liver and renal function
• Adequate bone marrow reserves

You may not qualify if…

• Prior chemotherapy, immunotherapy or biologic therapy for metastatic NSCLC
• Up to one prior adjuvant or neoadjuvant chemotherapy is allowed
• History of bone marrow transplantation or stem cell support
• Pregnant or lactating women

Where it is running

• East Bay Medical Oncology/Hematology Associates — Concord, California, United States
• Southwest Cancer Care — Escondido, California, United States
• Kaiser Permanente Medical Center — Hayward, California, United States
• Southwest Cancer Care — Murrieta, California, United States
• Kaiser Permanente Medical Center — Oakland, California, United States
• Southwest Cancer Care — Poway, California, United States
• Kaiser Permanente Medical Center — Sacramento, California, United States
• Kaiser Permanente Medical Center — San Francisco, California, United States
• Kaiser Permanente Medical Center — San Jose, California, United States
• Kaiser Permanente Medical Center — Santa Clara, California, United States
• Kaiser Permanente Medical Center — So. San Francisco, California, United States
• Kaiser Permanente Medical Center — Vallejo, California, United States
• Diablo Valley Oncology & Hematology Medical Group — Walnut Creek, California, United States
• Kaiser Permanente Medical Center — Walnut Creek, California, United States
• Citrus Hematology and Oncology — Crystal River, Florida, United States
• Citrus Hematology and Oncology Center — Inverness, Florida, United States
• Florida Wellcare Alliance, LC — Inverness, Florida, United States
• Kansas City Cancer Center — Kansas City, Kansas, United States
• Kansas City Cancer Center - Central Research Dept. Data Office & Drug Discovery Location — Lenexa, Kansas, United States
• Kansas City Cancer Center — Overland Park, Kansas, United States
• Department of Veterns Affairs - Overton Brooks VA Medical Center — Shreveport, Louisiana, United States
• LSU Health Sciences Center — Shreveport, Louisiana, United States
• University of Maryland, Baltimore University of Maryland Medical System-Greenebaum Cancer Center — Baltimore, Maryland, United States
• Center for Cancer and Blood Disorders, P. C. — Bethesda, Maryland, United States
• Bay Area Cancer Research Group — Concord, California, United States

Full record on ClinicalTrials.gov

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