Positron Emission Tomography Imaging of Dopamine Receptors Using the Tracer [11C]NNC-112

Completed · Phase 1

Conditions studied: Healthy

In brief

This study will investigate the use of \[11C\]NNC-112 in positron emission tomography (PET) scanning. PET is a technique that uses radioactive isotopes called tracers to provide images of the brain. Injected into the body, the isotopes lose their "radioactive strength" over time, sending out rays that can be picked up and "seen" by special detectors connected to a computer. The computer then makes a picture of the brain. This study will examine the distribution in the body of a new tracer called \[11C\]NNC-112. Healthy normal volunteers between 18 and 70 years of age may be eligible for this study. Candidates are screened with a physical examination and blood and urine tests, including a urine drug screen. Women up to age 55 also have a pregnancy test. Participants have a PET scan using the \[11C\]NNC-112 tracer. For this procedure, a catheter (small plastic tube) is placed into a vein in the subject's arm for injecting the tracer. Then, the subject lies on the scanner bed. After a preliminary "transmission scan," the tracer is injected, and PET scans are taken from the head to the upper thigh over a period of about 2 hours to show the distribution of radioactivity in the body. Blood pressure, breathing rate, and heart rate are checked before and after injection of the tracer, and blood and urine samples are collected after the PET scan.

Key facts

Study ID

NCT00088517

Run by

National Institute of Mental Health (NIMH)

People needed

10

Starts

2004-07-01

Expected to finish

2006-03-01

Last updated by the study team

2008-03-04

Who can join

Age: any. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• All subjects must be healthy and aged 18-70 years.

You may not qualify if…

• Current psychiatric disease, substance abuse or severe systemic disease based on history and physical exam
• Laboratory tests with clinically significant abnormalities
• More than moderate hypertension
• Any prior participation in other research protocols within the past year that involve radiation, with the exception of plain radiography studies (i.e., chest x-rays).
• Pregnancy and Breast Feeding
• Positive HIV test

Where it is running

• National Institute of Mental Health (NIMH) — Bethesda, Maryland, United States

Full record on ClinicalTrials.gov

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