Tanespimycin in Treating Patients With Stage III-IV Melanoma
Stopped early · Phase 2
Conditions studied: Recurrent Melanoma, Stage III Melanoma, Stage IV Melanoma
In brief
This phase II trial is studying how well tanespimycin works in treating patients with stage III or stage IV melanoma. Antitumor antibiotics such as tanespimycin may stop the growth of melanoma by stopping blood flow to the tumor.
Key facts
- Study ID
- NCT00087386
- Run by
- National Cancer Institute (NCI)
- People needed
- 50
- Starts
- 2004-06-01
- Last updated by the study team
- 2013-04-10
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Histologically or cytologically confirmed melanoma
- Stage III or IV disease
- No primary melanoma of the choroid or mucosa
- Measurable disease
- At least 1 unidimensionally measurable lesion >= 20 mm by conventional techniques OR >= 10 mm by spiral CT scan
- Tumor amenable to biopsy (for the first 10 patients in each stratum only)
- Patients must have measurable disease in addition to the tumor(s) to be biopsied
- No brain or epidural metastases
- Completely resected solitary brain metastases allowed provided patient has been free of CNS metastases for >= 6 months
- Performance status - Karnofsky 60-100%
- Performance status - ECOG 0-2
- More than 3 months
- Absolute neutrophil count >= 1,500/mm\^3
- Platelet count >= 100,000/mm\^3
- WBC >= 3,000/mm\^3
- AST and ALT =< 2.5 times upper limit of normal
- Creatinine normal
- No symptomatic congestive heart failure
- No unstable angina pectoris
- No cardiac arrhythmia
- No history of myocardial infarction
- No history of prolonged QTc interval
- No active ischemic heart disease within the past 12 months
- No uncontrolled dysrhythmia or dysrhythmias requiring medication
- No congenital prolonged QT syndrome
Where it is running
- Memorial Sloan-Kettering Cancer Center — New York, New York, United States
Full record on ClinicalTrials.gov
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