Joint Injections for Osteoarthritic Knee Pain

Completed · Phase 1/Phase 2

Conditions studied: Osteoarthritis

In brief

The purpose of this study is to determine whether prolotherapy (PrT), a therapy based on injection of a sugar solution in and around the knee, can decrease pain and disability from knee osteoarthritis (OA).

Key facts

Study ID

NCT00085722

Run by

University of Wisconsin, Madison

People needed

98

Starts

2004-07-01

Expected to finish

2016-05-01

Last updated by the study team

2019-02-15

Who can join

Age: 40 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Pain from knee osteoarthritis that has impacted life for 3 months to 10 years
• X-ray results indicating knee osteoarthritis

You may not qualify if…

• Knee osteoarthritis surgical candidate
• History of total knee joint repair
• Prior use of PrT
• Prior fracture of the knee joint
• Joint injection of steroids or other drugs within the past 3 months
• Rheumatoid or inflammatory arthritis
• Chronic use of narcotic medication
• Other chronic pain diagnoses
• diabetes mellitus
• Body mass index (BMI) greater than 45
• Unresolved litigation
• Pregnancy
• Co-morbidity that may interfere with the study

Where it is running

• Northeast Family Medical Center — Madison, Wisconsin, United States
• University of Wisconsin General Clinical Research Center — Madison, Wisconsin, United States

Full record on ClinicalTrials.gov

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