Cytokine Gene Polymorphisms in Bone Marrow Failure

Completed

Conditions studied: Bone Marrow Diseases

In brief

This study will examine whether cytokine gene polymorphisms affect the progression or response to therapy of bone marrow failure disorders. Cytokine genes instruct cells to produce proteins called cytokines that influence immune system response. As with many genes, the cytokine genes differ slightly from person to person. These differences are called gene polymorphisms. Different patients with the same bone marrow failure disease often progress and respond to treatment differently. This study will look at the possible role of cytokine gene polymorphisms in these differences. Patients between 2 and 80 years old who have participated in an NHLBI Hematology Branch treatment protocol for acquired aplastic anemia, myelodysplastic syndrome, or pure red cell aplasia are recruited to participate in this study. Blood collected and stored at the time of screening for the treatment protocol will be tested for cytokine gene polymorphisms. No additional tests, procedures, or treatments are involved in this study.

Key facts

Study ID
NCT00085670
Run by
National Heart, Lung, and Blood Institute (NHLBI)
People needed
79
Starts
2005-02-11
Expected to finish
2007-03-14
Last updated by the study team
2020-09-10

Who can join

Age: 2 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may not qualify if…

Where it is running

Full record on ClinicalTrials.gov

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