S0342: Paclitaxel, Carboplatin, and Cetuximab in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer

Completed · Phase 2

Conditions studied: Lung Cancer

In brief

RATIONALE: Drugs used in chemotherapy, such as paclitaxel and carboplatin, work in different ways to stop tumor cells from dividing so they stop growing or die. Monoclonal antibodies such as cetuximab can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells. Combining more than one chemotherapy drug with a monoclonal antibody may kill more tumor cells. It is not yet known whether cetuximab is more effective when given at the same time as chemotherapy or following chemotherapy. PURPOSE: This randomized phase II trial is studying how well giving cetuximab at the same time as combination chemotherapy works compared to giving cetuximab after combination chemotherapy in treating patients with stage IIIB or stage IV non-small cell lung cancer.

Key facts

Study ID

NCT00085501

Run by

SWOG Cancer Research Network

People needed

242

Starts

2004-07-01

Expected to finish

2011-07-01

Last updated by the study team

2012-11-01

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Arkansas Cancer Research Center at University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States
• Alta Bates Comprehensive Cancer Center — Berkeley, California, United States
• Peninsula Medical Center — Burlingame, California, United States
• City of Hope Comprehensive Cancer Center — Duarte, California, United States
• Marin Cancer Institute at Marin General Hospital — Greenbrae, California, United States
• Sutter Health Western Division Cancer Research Group — Greenbrae, California, United States
• Saint Rose Hospital — Hayward, California, United States
• Valley Memorial Hospital — Livermore, California, United States
• USC/Norris Comprehensive Cancer Center and Hospital — Los Angeles, California, United States
• Highland General Hospital — Oakland, California, United States
• CCOP - Bay Area Tumor Institute — Oakland, California, United States
• Summit Medical Center — Oakland, California, United States
• Comprehensive Cancer Center at Desert Regional Medical Center — Palm Springs, California, United States
• Sutter Roseville Medical Center — Roseville, California, United States
• Sutter Cancer Center — Sacramento, California, United States
• University of California Davis Cancer Center — Sacramento, California, United States
• Mercy General Hospital — Sacramento, California, United States
• California Pacific Medical Center - California Campus — San Francisco, California, United States
• J.C. Robinson, M.D. Regional Cancer Center — San Pablo, California, United States
• CCOP - Santa Rosa Memorial Hospital — Sana Rosa, California, United States
• St. Anthony Central Hospital — Denver, Colorado, United States
• University of Colorado Cancer Center at University of Colorado Health Sciences Center — Denver, Colorado, United States
• Veterans Affairs Medical Center - Denver — Denver, Colorado, United States
• Poudre Valley Hospital — Fort Collins, Colorado, United States
• Alaska Regional Hospital — Anchorage, Alaska, United States

Full record on ClinicalTrials.gov

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