Alemtuzumab Plus Fludarabine and Melphalan With or Without Cyclosporine, Mycophenolate Mofetil, and Low-Dose Total-Body Irradiation Therapy Followed by Donor Peripheral Stem Cell Transplant in Treating Patients With Hematologic Cancer
Withdrawn before enrolling · Phase 1/Phase 2
Conditions studied: Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Neoplasms
In brief
RATIONALE: Giving low doses of chemotherapy, monoclonal antibodies, and radiation therapy before a donor peripheral blood stem cell transplant helps stop the growth of cancer cells. It also stops the patient's immune system from rejecting the donor's stem cells when they do not exactly match the patient's blood. The donated stem cells may replace the patient's immune system and help destroy any remaining cancer cells (graft-versus-tumor effect). Sometimes the transplanted cells from a donor can also make an immune response against the body's normal cells. Giving cyclosporine and mycophenolate mofetil before transplant may stop this from happening. PURPOSE: This phase I/II trial is studying the side effects of alemtuzumab, fludarabine, and melphalan with or without cyclosporine, mycophenolate mofetil, and total-body irradiation before donor peripheral blood stem cell transplant and to see how well they work in treating patients with relapsed or refractory hematologic cancer.
Key facts
- Study ID
- NCT00085449
- Run by
- Alliance for Clinical Trials in Oncology
- People needed
- 0
- Starts
- 2006-05-01
- Expected to finish
- 2007-01-01
- Last updated by the study team
- 2019-11-27
Who can join
Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Moores UCSD Cancer Center — La Jolla, California, United States
- Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center — Los Angeles, California, United States
- UCSF Comprehensive Cancer Center — San Francisco, California, United States
- CCOP - Christiana Care Health Services — Newark, Delaware, United States
- Lombardi Comprehensive Cancer Center at Georgetown University Medical Center — Washington D.C., District of Columbia, United States
- University of Chicago Cancer Research Center — Chicago, Illinois, United States
- Holden Comprehensive Cancer Center at University of Iowa — Iowa City, Iowa, United States
- Massachusetts General Hospital Cancer Center — Boston, Massachusetts, United States
- Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute — Boston, Massachusetts, United States
- University of Minnesota Cancer Center — Minneapolis, Minnesota, United States
- Siteman Cancer Center at Barnes-Jewish Hospital — St Louis, Missouri, United States
- UNMC Eppley Cancer Center at the University of Nebraska Medical Center — Omaha, Nebraska, United States
- St. Joseph's Hospital and Medical Center — Paterson, New Jersey, United States
- Roswell Park Cancer Institute — Buffalo, New York, United States
- Don Monti Comprehensive Cancer Center at North Shore University Hospital — Manhasset, New York, United States
- Memorial Sloan-Kettering Cancer Center — New York, New York, United States
- Mount Sinai Medical Center — New York, New York, United States
- Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill — Chapel Hill, North Carolina, United States
- Duke Comprehensive Cancer Center — Durham, North Carolina, United States
- Wake Forest University Comprehensive Cancer Center — Winston-Salem, North Carolina, United States
- Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University — Columbus, Ohio, United States
- Western Pennsylvania Cancer Institute at Western Pennsylvania Hospital — Pittsburgh, Pennsylvania, United States
- Hollings Cancer Center at Medical University of South Carolina — Charleston, South Carolina, United States
- Virginia Commonwealth University Massey Cancer Center — Richmond, Virginia, United States
Full record on ClinicalTrials.gov
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