Analysis of Specimens From Individuals With Pulmonary Fibrosis

Running, not enrolling

Conditions studied: Pulmonary Fibrosis, Healthy Volunteers, Hermansky-Pudlak Syndrome (HPS)

In brief

The etiology of pulmonary fibrosis is unknown. Analyses of blood, genomic DNA, and specimens procured by bronchoscopy, lung biopsy, lung transplantation, clinically-indicated extra-pulmonary biopsies, or post-mortem examination from individuals with this disorder may contribute to our understanding of the pathogenic mechanisms of pulmonary fibrosis. The purpose of this protocol is to procure and analyze blood, genomic DNA, and specimens by bronchoscopy, lung biopsy, lung transplantation, extra-pulmonary biopsies, or post-mortem examination from subjects with pulmonary fibrosis. In addition, blood, genomic DNA, clinically-indicated extra-pulmonary biopsies, as well as bronchoscopy and post-mortem examination specimens may be procured and analyzed from relatives of subjects with hereditary forms of pulmonary fibrosis; blood, genomic DNA, and bronchoscopy specimens may be procured from healthy research volunteers....

Key facts

Study ID

NCT00084305

Run by

National Human Genome Research Institute (NHGRI)

People needed

315

Starts

2004-06-09

Last updated by the study team

2026-08-04

Who can join

Age: 18 and older, up to 115. Sex: any. Healthy volunteers: not accepted.

You may not qualify if…

• Individuals with any of the following:
• Significant inhalational exposure to fibrogenic fibers or dusts or exposure to drugs associated with pulmonary fibrosis,
• Uncontrolled ischemic heart disease,
• Uncorrectable bleeding diathesis,
• Pregnancy or lactation (excluded due to exposure of unnecessary risks), or
• Inability to give informed consent (excluded due to exposure of unnecessary risks).

Where it is running

• National Institutes of Health Clinical Center — Bethesda, Maryland, United States

Full record on ClinicalTrials.gov

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