Database for Stroke in Infants and Children: the International Pediatric Stroke Study

Recruiting now

Conditions studied: Cerebrovascular Accident, Focal Infarct

In brief

The International Pediatric Stroke Study (IPSS) was established in 2003 as a multi-center, multi-national clinical research registry. Over the years, it has grown to become a highly successful study vehicle for pediatric stroke research across over 100 institutions worldwide. Today, The IPSS continues to serve as the global clinical data and imaging core for multi-disciplinary pediatric experts who perform international collaborative research to better understand, prevent, and improve outcomes in pediatric stroke. The robust dataset and cohesive network enable high caliber and ground-breaking research in the field. Participating sites enroll neonates or children who have had an ischemic or hemorrhagic stroke, or may be at high risk of having a stroke. Participants have their medical and research records reviewed for information about their stroke and abstracted into a secure electronic database called REDCap, which is hosted at SickKids in Toronto Canada. The IPSS also provides an attractive imaging platform (through the Stroke Imaging Lab for Children, SILC, housed at SickKids) for sites to share clinically acquired brain images that will complement the clinical dataset. The clinical and imaging datasets will improve our understanding of the processes underlying plasticity and recovery in childhood stroke.

Key facts

Study ID

NCT00084292

Run by

The Hospital for Sick Children

People needed

12000

Starts

2003-01-01

Expected to finish

2030-12-01

Last updated by the study team

2025-05-15

Who can join

Age: any, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• This registry will include all children from birth to 18 years of age who are diagnosed with stroke or a condition/disease (as defined below) that put them at high risk of stroke after Jan 1,2003 at one of the IPSS participating sites.
• This registry will include children diagnosed with below stroke types:
• Arterial Ischemic Stroke (AIS),
• Cerebral Sinovenous Thrombosis (CSVT),
• AIS and CSVT
• Presume Preinatal Ischemic Stroke (PPIS)
• Children diagnosed with hemorrhagic stroke
• Children at high risk of stroke include:
• Those diagnosed with arteriopathy, arteritis/vasculitis, moyamoya, dissection, sickle cell related infarcts).
• Brain arteriovenous malformations

You may not qualify if…

• Premature children diagnosed with AIS.
• Premature children diagnosed with PPIS
• Children diagnosed with TIA (Transient Ischemic Attack)
• Brain hemorrhage secondary to trauma
• Refusal to provide consent for participation

Where it is running

• Hospital For Sick Children — Toronto, Ontario, Canada (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.