Cognition, Steroids, and Imaging in Cushings Disease

Completed

Conditions studied: Cushing Syndrome

In brief

This study investigates the effects of the glucocorticoid hormone cortisol on brain structure and function. Patients with Cushing's disease are studied before and after treatment. Brain imaging and neuropsychologic tests are used to study changes in the hippocampus and thinking and learning functions as well as mood during the period of elevated cortisol. At several intervals after treatment, these are reexamined to study the degree of reversibility of the abnormalities. The contribution of cortisol as well as testosterone and estrogen to dysfunction and recovery is studied. Since elevated cortisol and dysregulation of its secretory system occurs in a significant proportion of the aged and in Alzheimers Disease and Major Depressive Disorder, these studies will help advance knowledge of the role of cortisol in these conditions.

Key facts

Study ID

NCT00081341

Run by

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Expected to finish

2002-12-01

Last updated by the study team

2010-02-15

Who can join

Age: 9 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• patients with suspected Cushing's syndrome with clinical findings suggestive of Cushing's syndrome and positive screening tests (urinary free cortisol and low dose overnight dexamethasone suppression test).
• Exclusion criteria: none

Where it is running

• General Clinical Research Center, University of Michigan Health System — Ann Arbor, Michigan, United States

Full record on ClinicalTrials.gov

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