Safety and Efficacy Study of a Caspase Inhibitor in Patients Undergoing Liver Transplantation

Completed · Phase 2 · Has a placebo group

Conditions studied: Liver Transplantation, Hepatitis, Cholestasis, Carcinoma, Hepatocellular

In brief

The purpose of the study is to test the safety and effectiveness of IDN-6556 in preventing liver damage that normally occurs when livers are transported before being transplanted and in the immediate post-transplant period.

Key facts

Study ID

NCT00080236

Run by

Conatus Pharmaceuticals Inc.

People needed

99

Starts

2003-11-01

Expected to finish

2006-01-01

Last updated by the study team

2012-08-10

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Minimum adult age

You may not qualify if…

• Fulminant hepatic failure (UNOS Status I patients)
• Previous liver transplantation
• Patients undergoing split liver grafts
• Extrahepatic malignancy
• If female, pregnant or lactating

Where it is running

• Mayo Clinic Scottsdale — Phoenix, Arizona, United States
• University of California Los Angeles — Los Angeles, California, United States
• University of California San Francisco — San Francisco, California, United States
• Indiana University Medical Center — Indianapolis, Indiana, United States
• Tulane University Hospital and Clinic — New Orleans, Louisiana, United States
• Mayo Clinic Rochester — Rochester, Minnesota, United States
• Mount Sinai School of Medicine — New York, New York, United States
• University of Cincinnati — Cincinnati, Ohio, United States
• Baylor Regional Transplant Institute, Baylor University Medical Center — Dallas, Texas, United States
• The University of Texas Health Science Center at San Antonio — San Antonio, Texas, United States
• Oberarzt der Klinik für Allgemein-, Viszeral- und Transplantationschirurgie Charité-Virchow — Berlin, Germany
• Klinik für Viszeral- und Transplantationschirurgie Medizinische Hochschule Hannover — Hanover, Germany
• Abteilung für Transplantationschirurgie Johannes Gutenberg-Universität Mainz — Mainz, Germany

Full record on ClinicalTrials.gov

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