Study of Motexafin Gadolinium and Docetaxel for Advanced Solid Tumors
Completed · Phase 1
Conditions studied: Breast Neoplasms, Ovarian Neoplasms, Prostatic Neoplasms, Lung Neoplasms
In brief
The primary purpose of this study is to evaluate the safety, toxicities, and dosage for investigational drug Motexafin Gadolinium administered with docetaxel to patients with advanced solid tumors. Secondly, tumor response to the combined treatment will be evaluated.
Key facts
- Study ID
- NCT00080041
- Run by
- Pharmacyclics LLC.
- People needed
- 20
- Last updated by the study team
- 2007-05-15
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- ≥ 18 years old
- Histologically or cytologically confirmed diagnosis of cancer (i.e., Unresectable locally advanced or metastatic non-small-cell lung carcinoma (NSCLC) that had progressed during or after one or more chemotherapy regimens; Metastatic breast cancer; Hormone-refractory prostate cancer; Recurrent or refractory ovarian cancer; Sarcoma)
- ECOG performance status score either 0 or 1
- Willing and able to provide written informed consent
You may not qualify if…
- Laboratory Values of:
- Absolute neutrophil count < 2000/µL
- Platelet count < 100,00/µL
- AST or ALT > 1.5 x the upper limit of normal
- Alkaline phosphatase > 5 x the upper limit of normal
- Bilirubin > ULN
- Creatinine > 2.0 mg/dL
- and
- Peripheral neuropathy NCI CTC Grade 3 or higher
- Chemotherapy, radiation therapy, immunotherapy, or systemic biologic
- anticancer therapy within 21 days before beginning study treatment
- Known history of brain metastases or spinal cord compression
- Uncontrolled hypertension
- Myocardial infarction within 6 months before beginning study treatment
- Unstable angina pectoris, uncontrolled congestive heart failure, or uncontrolled serious arrhythmias
- Known sensitivity to or intolerable adverse effects from taxanes or polysorbate 80
- Known history of porphyria (testing not required at screening)
- Known history of glucose-6-phosphate dehydrogenase (G6PD) deficiency (testing not required at screening)
- Known history of HIV infection (testing not required at screening)
- Female who is pregnant or lactating (pregnancy test is required for all female patients of childbearing potential)
- Female of childbearing potential or sexually active male unwilling to use adequate contraceptive protection
- Physical or mental condition that makes patient unable to complete specified follow-up assessments
Where it is running
- University of Rochester Cancer Center — Rochester, New York, United States
Full record on ClinicalTrials.gov
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