High-Dose Chemotherapy Plus Autologous Stem Cell Transplantation Compared With Intermediate-Dose Chemotherapy Plus Autologous Stem Cell Transplantation With or Without Isotretinoin in Treating Young Patients With Recurrent High-Grade Gliomas
Completed · Phase 3
Conditions studied: Brain Tumor, Central Nervous System Tumor
In brief
RATIONALE: Drugs used in chemotherapy, such as carboplatin, thiotepa, and etoposide, work in different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with autologous stem cell transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more tumor cells. Isotretinoin may be effective in preventing recurrence of glioma. It is not yet known which regimen of chemotherapy plus autologous stem cell transplantation with or without isotretinoin is more effective in treating recurrent high-grade glioma. PURPOSE: This randomized phase III trial is studying high-dose chemotherapy or intermediate-dose chemotherapy followed by autologous stem cell transplantation to see how well it works compared to high-dose chemotherapy or intermediate-dose chemotherapy followed by autologous stem cell transplantation and isotretinoin in treating young patients with recurrent high-grade glioma.
Key facts
- Study ID
- NCT00078988
- Run by
- Children's Oncology Group
- People needed
- 1
- Starts
- 2004-10-01
- Expected to finish
- 2006-09-01
- Last updated by the study team
- 2015-05-07
Who can join
Age: any, up to 20. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Children's Hospital and Research Center - Oakland — Oakland, California, United States
- University of California Davis Cancer Center — Sacramento, California, United States
- Children's Hospital and Health Center - San Diego — San Diego, California, United States
- Children's Hospital Cancer Center — Denver, Colorado, United States
- Children's National Medical Center — Washington D.C., District of Columbia, United States
- University of Florida Shands Cancer Center — Gainesville, Florida, United States
- Nemours Children's Clinic — Jacksonville, Florida, United States
- University of Miami Sylvester Comprehensive Cancer Center — Miami, Florida, United States
- Miami Children's Hospital — Miami, Florida, United States
- All Children's Hospital — St. Petersburg, Florida, United States
- St. Joseph's Cancer Institute at St. Joseph's Hospital — Tampa, Florida, United States
- Kaplan Cancer Center at St. Mary's Medical Center — West Palm Beach, Florida, United States
- Emory University Hospital - Atlanta — Atlanta, Georgia, United States
- Cancer Research Center of Hawaii — Honolulu, Hawaii, United States
- Indiana University Cancer Center — Indianapolis, Indiana, United States
- St. Vincent Indianapolis Hospital — Indianapolis, Indiana, United States
- Kosair Children's Hospital — Louisville, Kentucky, United States
- CancerCare of Maine at Eastern Maine Medial Center — Bangor, Maine, United States
- Floating Hospital for Children at Tufts - New England Medical Center — Boston, Massachusetts, United States
- Barbara Ann Karmanos Cancer Institute — Detroit, Michigan, United States
- Spectrum Health Cancer Care - Butterworth Campus — Grand Rapids, Michigan, United States
- Van Elslander Cancer Center at St. John Hospital and Medical Center — Grosse Pointe Woods, Michigan, United States
- Children's Hospital of Minnesota - Minneapolis — Minneapolis, Minnesota, United States
- Fairview University Medical Center - University Campus — Minneapolis, Minnesota, United States
- Arkansas Cancer Research Center at University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States
Full record on ClinicalTrials.gov
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