Knee Stability Training for Knee Osteoarthritis (OA)

Completed · Phase 2

Conditions studied: Osteoarthritis, Joint Diseases

In brief

People with knee osteoarthritis (OA) frequently complain of knee instability. This study will test whether certain exercises can improve knee stability, reduce pain, and improve physical function in people with knee OA. Study hypotheses: 1) Participants in the stability training group will demonstrate less pain and higher levels of physical function, based on self-report measures of pain and function (WOMAC, Lower Extremity Function Scale), and less time to complete the Get Up and Go test, a physical performance measure of function. 2) During walking and the step down task, participants in the stability training group will demonstrate greater knee motion during weight bearing, greater vertical ground reaction forces and loading rates, and reduced ratios of co-contraction between quadriceps/hamsting and tibialis anterior/gastrocnemius muscle pairs compared to the standard group. Participants in the stability group will also demonstrate greater step lengths, single limb support times, and average walking velocity compared to the standard group.

Key facts

Study ID

NCT00078624

Run by

University of Pittsburgh

People needed

231

Starts

2004-04-01

Expected to finish

2008-12-01

Last updated by the study team

2013-01-24

Who can join

Age: 40 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Meet the 1986 American College of Rheumatology (ACR) clinical criteria for knee osteoarthritis
• Grade II or greater Kellgren and Lawrence radiographic changes

You may not qualify if…

• History of two or more falls within the year prior to study entry
• Unable to walk a distance of 100 feet without an assistive device or a rest period
• Total knee arthroplasty
• Uncontrolled hypertension
• History of cardiovascular disease
• History of neurological disorders that affect lower extremity function such as stroke or peripheral neuropathy
• Corticosteroid injection to the quadriceps or patellar tendon in the past month, or 3 or more within the past year
• Quadriceps tendon rupture, patellar tendon rupture, or patellar fracture that could place them at risk of re-injury during quadriceps strength testing
• Pregnancy

Where it is running

• University of Pittsburgh, Department of Physical Therapy, School of Health and Rehabilitation Sciences — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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