Evaluation of the Age-Related Eye Disease Study (AREDS) Clinical Lens Grading System

Completed

Conditions studied: Cataract

In brief

This study will evaluate a system developed to grade the severity of age-related cataract, a common cause of vision loss in older adults. Cataract research requires methods to simply and accurately determine the type and severity of cataracts in order to develop new, possibly non-surgical, treatments. Patients 50 years of age and older with one of the three major age-related cataract types (nuclear, cortical, and posterior subcapsular) may be eligible for this study. Participants will be recruited from among patients enrolled in other National Eye Institute protocols. Participants will have their eyes examined independently by two ophthalmologists with a biomicroscope, a magnifying device routinely used during eye examinations. The doctors will use the new grading system to record if a cataract is present, and if so, how severe it is. The examination includes measurement of visual acuity (vision chart test) and examination of the lens, retina, pupils and eye movements. Photographs of the eye will be taken using a special camera that flashes a bright light in the eye.

Key facts

Study ID

NCT00078299

Run by

National Eye Institute (NEI)

People needed

150

Starts

2004-02-01

Expected to finish

2005-04-01

Last updated by the study team

2008-03-04

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient must understand and sign the informed consent.
• Patient must be at least 18 years of age.
• Pupillary dilation to at least 6 mm must be possible.
• Patients must have at least one natural lens present.

You may not qualify if…

• Patients below the age of 18 will be excluded from participation in this study of age-related cataract.
• Any condition such as corneal opacification that precludes adequate slit lamp examination and photography of the lens.

Where it is running

• National Eye Institute (NEI) — Bethesda, Maryland, United States

Full record on ClinicalTrials.gov

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