Antidepressant Medication Treatment for Depression in Individuals With Chronic Heart Failure

Completed · Phase 2/Phase 3 · Has a placebo group

Conditions studied: Heart Failure, Congestive, Chronic Heart Failure, Depression

In brief

This study will examine the effect of antidepressant medication on rates of death and disease in depressed people with chronic heart failure.

Key facts

Study ID

NCT00078286

Run by

Duke University

People needed

469

Starts

2003-11-01

Expected to finish

2008-09-01

Last updated by the study team

2013-02-27

Who can join

Age: 45 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Chronic heart failure
• Diagnostic and Statistical Manual- Fourth Edition (DSM-IV) criteria for major depression
• Current use of any antipsychotic medication at study entry

You may not qualify if…

• Life-threatening comorbidity with a 50% or higher likelihood of death within 1 year
• History of psychoses, bipolar disorder, or severe personality disorder
• History of alcohol or drug dependence in the last year
• Severe physical disability that may interfere with the study
• Neurological impairment
• Active suicidal ideations
• Current use of antidepressant medication(s) at the start of study medication

Where it is running

• Duke Medical Center — Durham, North Carolina, United States

Full record on ClinicalTrials.gov

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