Captopril in Treating Patients With Non-Small Cell Lung Cancer or Limited-Stage Small Cell Lung Cancer That Has Been Previously Treated With Radiation Therapy With or Without Chemotherapy

Stopped early · Phase 2

Conditions studied: Lung Cancer, Pulmonary Complications, Radiation Fibrosis

In brief

RATIONALE: Captopril is a drug that may be able to decrease side effects caused by radiation therapy, and may improve the quality of life of patients with non-small cell lung cancer or limited-stage small cell lung cancer. PURPOSE: This randomized phase II trial is studying how well captopril works in decreasing side effects and improving the quality of life in patients who have received radiation therapy with or without chemotherapy for stage I, stage II, or stage IIIB non-small cell lung cancer or limited-stage small cell lung cancer.

Key facts

Study ID

NCT00077064

Run by

Radiation Therapy Oncology Group

People needed

81

Starts

2003-06-01

Expected to finish

2016-12-01

Last updated by the study team

2018-03-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Fairfield Medical Center — Lancaster, Ohio, United States
• Lima Memorial Hospital — Lima, Ohio, United States
• Strecker Cancer Center at Marietta Memorial Hospital — Marietta, Ohio, United States
• Northwest Ohio Oncology Center — Maumee, Ohio, United States
• St. Luke's Hospital — Maumee, Ohio, United States
• Licking Memorial Cancer Care Program at Licking Memorial Hospital — Newark, Ohio, United States
• St. Charles Mercy Hospital — Oregon, Ohio, United States
• Toledo Clinic - Oregon — Oregon, Ohio, United States
• Firelands Regional Medical Center — Sandusky, Ohio, United States
• North Coast Cancer Care, Incorporated — Sandusky, Ohio, United States
• Mercy Medical Center — Springfield, Ohio, United States
• Community Hospital of Springfield and Clark County — Springfield, Ohio, United States
• Flower Hospital Cancer Center — Sylvania, Ohio, United States
• Mercy Hospital of Tiffin — Tiffin, Ohio, United States
• Toledo Hospital — Toledo, Ohio, United States
• St. Vincent Mercy Medical Center — Toledo, Ohio, United States
• Medical University of Ohio Cancer Center — Toledo, Ohio, United States
• CCOP - Toledo Community Hospital — Toledo, Ohio, United States
• Toledo Clinic, Incorporated - Main Clinic — Toledo, Ohio, United States
• Fulton County Health Center — Wauseon, Ohio, United States
• Mount Carmel St. Ann's Cancer Center — Westerville, Ohio, United States
• Genesis - Good Samaritan Hospital — Zanesville, Ohio, United States
• CCOP - Greenville — Greenville, South Carolina, United States
• Rapid City Regional Hospital — Rapid City, South Dakota, United States
• Fremont Memorial Hospital — Fremont, Ohio, United States

Full record on ClinicalTrials.gov

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