Leukapheresis for Research on HCV-Coinfected Patients
Completed
Conditions studied: Hepatitis C, HIV Infections
In brief
This study will collect quantities of white blood cells from patients infected with the hepatitis C virus (HCV) for research on the interactions between HCV and the human immunodeficiency virus (HIV) in people infected with both of these agents. Several studies have shown that infection with HIV adversely affects liver disease due to HCV. Patients 18 years of age and older who are infected with both HCV and HIV or with HCV alone may be eligible for this study. Candidates must not have liver failure and must not be undergoing treatment for HCV at the time of enrollment. Participants will undergo leukapheresis to collect white blood cells. This procedure allows collection of larger numbers of cells than would be possible with simple blood drawing. For the procedure, blood is removed through a needle in the vein of one arm and spun in a machine that separates the blood into its components. The white cells are extracted and the rest of the blood is re-infused through the same needle or through a needle in the other arm. The procedure takes approximately 1-3 hours, depending on the amount of white cells being collected. A maximum of three leukapheresis procedures are done. If additional procedures are required, the patient will sign a new consent form. Procedures will be limited to no more than three times a year, or once every 4 months.
Key facts
- Study ID
- NCT00076427
- Run by
- National Institute of Allergy and Infectious Diseases (NIAID)
- People needed
- 327
- Starts
- 2004-01-14
- Expected to finish
- 2015-06-09
- Last updated by the study team
- 2017-10-06
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Family and Medical Counseling Service — Washington D.C., District of Columbia, United States
- Unity Health Care/Walker Jones — Washington D.C., District of Columbia, United States
- Whitman Walker Clinic — Washington D.C., District of Columbia, United States
- National Institutes of Health Clinical Center, 9000 Rockville Pike — Bethesda, Maryland, United States
Full record on ClinicalTrials.gov
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