Preliminary Study of Safety and Efficacy of Nanocrystalline Silver Cream in Atopic Dermatitis (Eczema)
Completed · Phase 2
Conditions studied: Atopic Dermatitis, Eczema
In brief
Nanocrystalline silver (very small particles of silver) is the active ingredient in Acticoat dressings, which have been approved for the treatment of burns and other wounds. Silver has been used for decades as an effective antimicrobial agent. In animal studies, nanocrystalline silver cream (NPI) has also demonstrated anti-inflammatory activity. Thus, nanocrystalline silver cream is being evaluated in the treatment of inflammatory skin conditions such as atopic dermatitis (eczema). Approximately 180 study subjects with a definitive diagnosis of mild to moderate eczema will be enrolled in this study. Subjects will be randomly assigned to treatment with placebo, 0.5% NPI or 1% NPI for the 6-week treatment period. Assessments of treatment effect and safety will be performed weekly. Upon completion of the study, subjects may be eligible for 12 weeks of open-label treatment with 1% NPI.
Key facts
- Study ID
- NCT00076375
- Run by
- Nucryst Pharmaceuticals
- People needed
- 180
- Starts
- 2003-11-01
- Expected to finish
- 2004-04-01
- Last updated by the study team
- 2005-06-24
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Radiant Research — Birmingham, Alabama, United States
- Medical Affliated Research Centers, Inc. — Huntsville, Alabama, United States
- National Jewish Medical & Research Center — Denver, Colorado, United States
- nTouch Research — Washington D.C., District of Columbia, United States
- Radiant Research — West Palm Beach, Florida, United States
- Radiant Research — Boise, Idaho, United States
- Radiant Research — Overland Park, Kansas, United States
- Radiant Research — St Louis, Missouri, United States
- Sadick Dermatology & Aesthetic Surgery — New York, New York, United States
- Mount Sinai School of Medicine — New York, New York, United States
- Clinical Research of Winston-Salem, Inc. — Winston-Salem, North Carolina, United States
- University Hospitals of Cleveland — Cleveland, Ohio, United States
- Radiant Research — Columbus, Ohio, United States
- Oregon Health & Science University — Portland, Oregon, United States
- Radiant Research — Philadelphia, Pennsylvania, United States
- National Allergy, Asthma & Urticaria Centers of Charleston, P.A. — Charleston, South Carolina, United States
- Radiant Research — Greer, South Carolina, United States
- ACE Research Specialists, Inc. — Nashville, Tennessee, United States
- Radiant Research — Lakewood, Washington, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.