Adding Exercise to Antidepressant Medication Treatment for Depression

Completed · Not applicable

Conditions studied: Depression

In brief

This study will assess the effectiveness of an exercise program in improving antidepressant medication treatment for individuals with major depressive disorder (MDD).

Key facts

Study ID

NCT00076258

Run by

University of Texas Southwestern Medical Center

People needed

126

Starts

2003-04-01

Expected to finish

2007-08-01

Last updated by the study team

2020-09-23

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of Major Depressive Disorder
• Score of 14 or higher on the Hamilton Depression Scale (HAM-D)
• 8 to 12 weeks of SSRI treatment, with at least 6 weeks at adequate doses
• Sedentary lifestyle
• Physically capable of exercise
• Body mass index (BMI) less than 40 kg/m2
• Willing and able to comply with study requirements

You may not qualify if…

• Significant cardiovascular disease or other medical conditions
• Uncontrolled hypertension
• Abnormal exercise stress test
• Hematologic disorders
• Comorbid disorders, including depression due to another comorbid condition, psychotic disorder, bipolar disorder, schizophrenia, schizoaffective disorder, eating disorder, or obsessive compulsive disorder (OCD)
• Alcohol and/or substance abuse in the past 6 months
• Hospitalization for mental illness within the past year
• High suicide risk
• Use of psychopharmacological or psychotherapeutic treatment other than SSRIs
• Failure to respond to two or more adequate pharmacological treatments during the current depressive episode
• Significantly elevated blood lipids
• Pregnancy

Where it is running

• University of Texas Southwestern Medical Center at Dallas — Dallas, Texas, United States

Full record on ClinicalTrials.gov

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