S0226 Anastrozole With or Without Fulvestrant as First-Line Therapy in Postmenopausal Women With Metastatic Breast Cancer
Completed · Phase 3
Conditions studied: Breast Cancer
In brief
RATIONALE: Estrogen can stimulate the growth of breast cancer cells. Hormone therapy using drugs such as anastrozole and fulvestrant may fight breast cancer by blocking the use of estrogen. It is not yet known whether anastrozole is more effective with or without fulvestrant in treating breast cancer. PURPOSE: This randomized phase III trial is studying giving anastrozole together with fulvestrant to see how well it works compared to anastrozole alone as first-line therapy in treating postmenopausal women with metastatic breast cancer.
Key facts
- Study ID
- NCT00075764
- Run by
- SWOG Cancer Research Network
- People needed
- 695
- Starts
- 2004-04-01
- Expected to finish
- 2018-10-01
- Last updated by the study team
- 2021-01-13
Who can join
Age: 18 and older. Sex: female. Healthy volunteers: not accepted.
Where it is running
- Providence Cancer Center at Providence Hospital — Mobile, Alabama, United States
- Alaska Regional Hospital Cancer Center — Anchorage, Alaska, United States
- Providence Cancer Center — Anchorage, Alaska, United States
- Arizona Cancer Center at University of Arizona Health Sciences Center — Tucson, Arizona, United States
- Highlands Oncology Group - Springdale — Bentonville, Arkansas, United States
- Hembree Mercy Cancer Center at St. Edward Mercy Medical Center — Fort Smith, Arkansas, United States
- City of Hope Comprehensive Cancer Center — Duarte, California, United States
- Glendale Memorial Hospital Comprehensive Cancer Center — Glendale, California, United States
- Loma Linda University Cancer Institute at Loma Linda University Medical Center — Loma Linda, California, United States
- USC/Norris Comprehensive Cancer Center and Hospital — Los Angeles, California, United States
- Tibotec Therapeutics - Division of Ortho Biotech Products, LP — Marysville, California, United States
- University of California Davis Cancer Center — Sacramento, California, United States
- San Francisco General Hospital Medical Center — San Francisco, California, United States
- CCOP - Santa Rosa Memorial Hospital — Santa Rosa, California, United States
- Tahoe Forest Cancer Center — Truckee, California, United States
- University of Colorado Cancer Center at UC Health Sciences Center — Aurora, Colorado, United States
- Memorial Hospital Cancer Center - Colorado Springs — Colorado Springs, Colorado, United States
- Denver Health Medical Center — Denver, Colorado, United States
- Veterans Affairs Medical Center - Denver — Denver, Colorado, United States
- Shaw Regional Cancer Center — Edwards, Colorado, United States
- Valley View Hospital Cancer Center — Glenwood Springs, Colorado, United States
- Middlesex Hospital Cancer Center — Middletown, Connecticut, United States
- Walter Reed Army Medical Center — Washington D.C., District of Columbia, United States
- Eugene M. and Christine E. Lynn Cancer Institute at Boca Raton Community Hospital - Main Campus — Boca Raton, Florida, United States
- Regional Medical Center — Anniston, Alabama, United States
Full record on ClinicalTrials.gov
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