S0205 Gemcitabine w/ or w/o Cetuximab as First-Line Therapy in Locally Advanced Pancreas Cancer

Completed · Phase 3

Conditions studied: Pancreatic Cancer

In brief

RATIONALE: Drugs used in chemotherapy, such as gemcitabine, work in different ways to stop tumor cells from dividing so they stop growing or die. Monoclonal antibodies, such as cetuximab, can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells. It is not yet known whether gemcitabine is more effective with or without cetuximab in treating pancreatic cancer. PURPOSE: This randomized phase III trial is studying giving gemcitabine together with cetuximab to see how well it works compared to giving gemcitabine alone as first-line therapy in treating patients with locally advanced unresectable or metastatic adenocarcinoma of the pancreas.

Key facts

Study ID

NCT00075686

Run by

SWOG Cancer Research Network

People needed

766

Starts

2004-01-01

Expected to finish

2009-04-01

Last updated by the study team

2015-11-17

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

• East Alabama Medical Center — Opelika, Alabama, United States
• Alaska Regional Hospital Cancer Center — Anchorage, Alaska, United States
• Cancer Center at Providence Alaska Medical Center — Anchorage, Alaska, United States
• Banner Thunderbird Medical Center — Glendale, Arizona, United States
• Banner Good Samaritan Medical Center — Phoenix, Arizona, United States
• CCOP - Western Regional, Arizona — Phoenix, Arizona, United States
• Hembree Mercy Cancer Center at St. Edward Mercy Medical Center — Fort Smith, Arkansas, United States
• Highlands Oncology Group - Springdale — Springdale, Arkansas, United States
• Alta Bates Comprehensive Cancer Center — Berkeley, California, United States
• Peninsula Medical Center — Burlingame, California, United States
• Mount Diablo Regional Cancer Center — Concord, California, United States
• City of Hope Comprehensive Cancer Center — Duarte, California, United States
• California Cancer Center - Woodward Park Office — Fresno, California, United States
• Virginia K. Crosson Cancer Center at St. Jude Medical Center — Fullerton, California, United States
• Marin Cancer Institute at Marin General Hospital — Greenbrae, California, United States
• Sutter Health Western Division Cancer Research Group — Greenbrae, California, United States
• Saint Rose Hospital — Hayward, California, United States
• Loma Linda University Cancer Institute at Loma Linda University Medical Center — Loma Linda, California, United States
• Highland General Hospital at St. George's University School of Medicine — Oakland, California, United States
• CCOP - Bay Area Tumor Institute — Oakland, California, United States
• Summit Medical Center — Oakland, California, United States
• Chao Family Comprehensive Cancer Center at University of California Irvine Medical Center — Orange, California, United States
• Valley Care Medical Center — Pleasanton, California, United States
• University of California Davis Cancer Center — Sacramento, California, United States
• Mobile Infirmary Medical Center — Mobile, Alabama, United States

Full record on ClinicalTrials.gov

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