Methotrexate, Cyclophosphamide, and Etoposide Phosphate Given With Osmotic Blood-Brain Barrier Disruption Plus Dexamethasone and Cytarabine in Treating Patients With Primary CNS Lymphoma
Completed · Phase 2
Conditions studied: Lymphoma
In brief
RATIONALE: Drugs used in chemotherapy, such as methotrexate, cyclophosphamide, etoposide phosphate, dexamethasone, and cytarabine, work in different ways to stop cancer cells from dividing so they stop growing or die. Osmotic blood-brain barrier disruption uses certain drugs to open the blood vessels around the brain and allow anticancer substances to be delivered directly to the brain. Giving methotrexate, cyclophosphamide, and etoposide phosphate with osmotic blood-brain barrier disruption plus dexamethasone and cytarabine may kill more cancer cells. PURPOSE: Phase II trial to study the effectiveness of giving methotrexate, cyclophosphamide, and etoposide phosphate with osmotic blood-brain barrier disruption plus dexamethasone and cytarabine in treating patients who have primary CNS lymphoma.
Key facts
- Study ID
- NCT00074178
- Run by
- OHSU Knight Cancer Institute
- People needed
- 22
- Starts
- 2000-01-01
- Expected to finish
- 2006-07-01
- Last updated by the study team
- 2017-04-21
Who can join
Age: 16 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Oregon Health & Science University Cancer Institute — Portland, Oregon, United States
Full record on ClinicalTrials.gov
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