Study Evaluating CMC-544 In B-Cell Non-Hodgkin's Lymphoma

Completed · Phase 1

Conditions studied: Lymphoma, B-Cell

In brief

To determine the Maximum Tolerated Dose (MTD), the tolerability, and the initial safety profile of CMC-544 in subjects with B-cell Non-Hodgkin's Lymphoma (NHL).

Key facts

Study ID

NCT00073749

Run by

Pfizer

People needed

79

Starts

2003-08-01

Expected to finish

2010-12-01

Last updated by the study team

2018-12-17

Who can join

Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subjects who have been previously diagnosed with CD22-positive, B-cell NHL, according to WHO classification, which has progressed after at least 2 prior therapies of probable clinical benefit
• At the expanded cohort, part 2 of the study, subjects must have one of the following:
• Follicular lymphoma previously treated with at least one dose of rituximab, but have not received radioimmunotherapy
• Diffuse large B-cell lymphoma
• Age 18 years or older

You may not qualify if…

• Candidate for potentially curative therapies in the opinion of the investigator
• Chronic lymphocytic leukemia
• Burkitt's lymphoma, primary effusion lymphoma, and precursor B-cell lymphoblastic lymphoma

Where it is running

• UAB CCC Clinical Studies Unit — Birmingham, Alabama, United States
• University of Alabama at Birmingham Kirklin Clinic — Birmingham, Alabama, United States
• UAB Russell Ambulatory Pharmacy — Birmingham, Alabama, United States
• University of Alabama at Birmingham — Birmingham, Alabama, United States
• Northwestern Medical Faculty Foundation — Chicago, Illinois, United States
• Northwestern Memorial Hospital — Chicago, Illinois, United States
• Roswell Park Cancer Institute — Buffalo, New York, United States
• The Cleveland Clinic Foundation — Cleveland, Ohio, United States
• University of Pennsylvania — Philadelphia, Pennsylvania, United States
• Fox Chase Cancer Center — Philadelphia, Pennsylvania, United States
• M.D. Anderson Cancer Center — Houston, Texas, United States
• Universitair Ziekenhuis Gasthuisberg — Leuven, Belgium
• Hopital Saint Louis — Paris, France
• Centre Hospitalier Lyon-Sud — Pierre-Bénite, France
• Universitätsklinikum Bonn — Bonn, North Rhine-Westphalia, Germany
• Universitaetsmedizin der Johannes Gutenberg-Universitaet — Mainz, Germany
• Medizinische Klinik und Poliklinik III, Klinikum der Universitat Muenchen-Grosshadern — München, Germany
• Universitaet Muenchen Klinikum Grosshadern — München, Germany
• Hospital de la Santa Creu I Sant Pau — Barcelona, Spain
• Hospital Clinic I Provincial — Barcelona, Spain
• Centre Hospitalier Universitaire Vaudois — Lausanne, Switzerland
• St Bartholomew's Hospital — London, United Kingdom

Full record on ClinicalTrials.gov

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