Low-Dose Leptin and the Formerly-Obese
Status unconfirmed · Phase 3
Conditions studied: Obesity
In brief
Our previous studies have demonstrated that there is substantial metabolic opposition to the maintenance of an altered body weight. Leptin is a protein secreted by fat cells and the circulating concentrations of leptin are directly proportional to fat mass. Leptin-deficiency is associated with severe obesity in rodents and in humans and the obesity is relieved by leptin administration. These studies examine the hypothesis that some of this metabolic opposition cto the maintenance of an altered body weight can be relieved by restoring circulating concentrations of the hormone leptin to the same range as at usual body weight in subjects who are maintaining a reduced body weight. The basic design of this study is to observe subjects at a 10% reduced body weight and then again at that reduced body weight while receiving physiological leptin or T3 supplementation.
Key facts
- Study ID
- NCT00073242
- Run by
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- People needed
- 25
- Starts
- 2000-07-01
- Expected to finish
- 2015-07-01
- Last updated by the study team
- 2015-06-04
Who can join
Age: 19 and older, up to 45. Sex: any. Healthy volunteers: accepted.
Where it is running
- Columbia Presbyterian Medical Center — New York, New York, United States (enrolling)
Full record on ClinicalTrials.gov
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