A Humanized Anti-Interferon-γ Monoclonal Antibody (HuZAF) for Moderate to Severe Crohn's Disease
Completed · Phase 2
Conditions studied: Crohn's Disease, Colitis, Intestinal Disease, Gastrointestinal Disease, Digestive System Disease
In brief
The purpose of the HARMONY study is to assess the safety and efficacy of an investigational drug called HuZAF, in patients with moderate to severe Crohn's disease (CD). HuZAF is a humanized anti-Interferon-gamma (anti-IFN-γ) monoclonal antibody, which binds and blocks IFN-γ, a protein in the immune system that is involved in inflammation. Antibodies are proteins normally produced by our immune system to help fight off foreign substances. Scientists have been able to make therapeutic humanized monoclonal antibodies, similar to the antibodies in our bodies, to target diseases.
Key facts
- Study ID
- NCT00072943
- Run by
- Facet Biotech
- People needed
- 175
- Starts
- 2002-03-01
- Expected to finish
- 2004-04-01
- Last updated by the study team
- 2012-03-13
Who can join
Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Advanced Clinical Research Institute — Anaheim, California, United States
- Doctor's Office — Orange, California, United States
- Gainesville VA Medical Center — Gainesville, Florida, United States
- Waterside Clinical Research Services, Inc. — West Palm Beach, Florida, United States
- Atlanta Gastroenterology Associates — Atlanta, Georgia, United States
- Doctor's Office — Chicago, Illinois, United States
- University of Kentucky Medical Center, Division of Digestive Disease & Nutrition — Lexington, Kentucky, United States
- Massachusetts General Hospital, Gastrointestinal Unit — Boston, Massachusetts, United States
- Gastroenterology Specialities P.C. — Lincoln, Nebraska, United States
- Carolina Digestion Health Associates — Charlottesville, North Carolina, United States
- Consultants for Clinical Research — Cincinnati, Ohio, United States
- The Cleveland Clinic Foundation — Cleveland, Ohio, United States
- University Pittsburgh Medical Center, Division of Gastroenterology, Hepatology and Nutrition, Inflammatory Bowel Disease Center — Pittsburgh, Pennsylvania, United States
- Houston Medical Research Associates — Houston, Texas, United States
- University of Virginia Health System — Charlottesville, Virginia, United States
- Vancouver General Hospital, Dept. of Medicine — Vancouver, British Columbia, Canada
- Health Science Centre — Winnipeg, Manitoba, Canada
- Queen Elizabeth II Health Science Center, McKenzie Building, Pathology — Halifax, Nova Scotia, Canada
- London Health Science Center, University Campus — London, Ontario, Canada
Full record on ClinicalTrials.gov
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