Valproate in Dementia (VALID)

Completed · Phase 3 · Has a placebo group

Conditions studied: Alzheimer Disease

In brief

The purpose of this trial is to demonstrate whether valproate therapy delays the emergence of agitation and/or psychosis in outpatients with probable Alzheimer's disease (AD) who have not experienced agitation and psychosis in their illness. A secondary aim is to determine whether valproate therapy delays the progression of cognitive and functional measures of the illness. This trial will also assess the tolerability and safety of low-dose, long-term valproate therapy. Valproate, an anticonvulsant drug, was selected because of its possible symptomatic efficacy for agitation in AD, known safety profile in numerous clinical populations, and in view of recent data supporting its neuroprotective potential in AD.

Key facts

Study ID

NCT00071721

Run by

Alzheimer's Disease Cooperative Study (ADCS)

People needed

313

Starts

2003-10-01

Expected to finish

2009-12-01

Last updated by the study team

2014-09-25

Who can join

Age: 55 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Probable AD by National Institute of Neurological Disorders and Stroke (NINDS)-Alzheimer's Disease and Related Disorder Association (ADRDA) criteria.
• Males or females.
• > 55 and < 90 years of age.
• Weight > 40 kg (88.2 lbs.).
• Residing in the community at Screen and Baseline. Participants may reside in assisted living facilities, but not in long-term care nursing facilities or assisted living facilities that provide intensive support for people with dementia nor may they reside in a secure unit necessary for behavioral management.
• Mini Mental State Examination (MMSE) at Screen and Baseline 12-20 inclusive.
• Computed tomography (CT) or magnetic resonance imaging (MRI) since onset of dementia consistent with the diagnosis of probable AD. Single lacunes in non-critical areas and non-specific white matter changes that are interpreted as age-related are not grounds for exclusion. Any ambiguous scan results must be reviewed with the Project Director.
• Fluent in English or Spanish.
• Supervision available for study medication.
• Study partner to accompany subject to all visits.
• Study partner must have in-person contact with the participant > 2 days/week.
• Able to ingest oral medication.
• Total Neuropsychiatric Inventory (NPI) score for previous 4 weeks < 8 at Screening, and for the period between Screening and Baseline.
• NPI item score for the items assessing delusions, hallucinations, agitation/aggression all greater than or equal to 1 for 4 weeks prior to Screening (less than once/week and mild severity at most) and for the period between Screening and Baseline.
• Scores of greater than or equal to 1 for items rating delusions, hallucinations, and agitation/aggression taken from the NPI, modified to assess these features since onset of illness. This will be derived from a second interview with the modified NPI. (Agitation/psychosis during episodes of delirium are not considered exclusionary.).

You may not qualify if…

• Exceptions to these criteria may be considered on a case-by-case basis at the discretion of the Project Director:
• Non-AD dementia.
• Females of child-bearing potential.
• Residence in a long-term care facility or equivalent at Baseline.
• Presence or previous history of agitation or psychosis requiring active psychotropic medication since the illness began.
• History of clinically significant stroke.
• Current evidence or history in past two years of: focal brain lesion, head injury with loss of consciousness or Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV) criteria for any major psychiatric disorder including psychosis, major depression, bipolar disorder, alcohol or substance abuse.
• Sensory impairment that would prevent subject from participating in or cooperating with the protocol.
• Medical contraindications to study participation.
• Use of another investigational agent within two months prior to Screening.
• Evidence of any significant clinical disorder or laboratory finding that renders the subject unsuitable for receiving an investigational new drug including clinically significant or unstable hematologic, hepatic, cardiovascular, pulmonary, gastrointestinal, endocrine, metabolic, renal, or other systemic disease or laboratory abnormality.
• Clinical contraindication to the use of valproate (e.g., known hypersensitivity or allergic reactions, severe neutropenia, severe hepatic disease, or urea cycle disorder. A urea cycle disorder should be considered in patients with history of unexplained encephalopathy following protein meals, or family history of urea cycle disorder).
• History of seizure within past 5 years prior to Screening.
• Platelet count < 100,000/mm\^3.
• International Normalized Ratio (INR) > 1.2 or partial thromboplastin time (PTT) > 40 seconds.
• Active neoplastic disease. Exceptions: skin tumors other than melanoma are not excluded; patients with stable prostate cancer may be included at the discretion of the Project Director; women who have been treated for breast cancer and have no metastases and whose survival is expected to exceed 2 years may be considered for inclusion on a case-by-case basis in consultation with the Project Director; patients with purely localized bladder wall cancers may be included at the discretion of the Project Director.
• Excluded Medications:
• Use of psychotropics for treatment of agitation or psychosis. Antidepressants used in stable doses for 3 months prior to Screening to treat depression or anxiety, but not agitation, will be permitted. Low dose sedatives for sleep, but not agitation, will be permitted. Cholinesterase inhibitors used in stable doses for at least 3 months prior to Screening are permitted.
• Regular use of narcotic analgesics within 3 months of Screening.
• Anti-parkinsonian medications (e.g. levodopa, selegiline, pergolide, bromocriptine, pramipexole) within 2 months of Screening.
• Use of drugs with significant central anticholinergic or antihistaminic effects (eg, benztropine, trihexyphenidyl, dicyclomine, diphenhydramine, cyproheptadine, diphenoxylate, hydroxyzine, meclizine, prochlorperazine, promethazine) within 2 months of Screening.
• Use of other investigational drug studies within two months prior to Screening.
• Use of other anticonvulsants within 5 years prior to Screening.
• Use of zidovudine at any time.
• Use of tricyclic antidepressants within 1 month prior to Screening.

Where it is running

• Sun Health Research Institute — Sun City, Arizona, United States
• University of Arizona — Tucson, Arizona, United States
• University of California, Irvine — Irvine, California, United States
• University of California, ADRC, San Diego — La Jolla, California, United States
• VA Healthcare System Long Beach — Long Beach, California, United States
• University of Southern California — Los Angeles, California, United States
• University of California ADRC — Los Angeles, California, United States
• University of California, LA (Olive View) — Los Angeles, California, United States
• Pacific Research Network — San Diego, California, United States
• Stanford University, VA Aging Clinical Research Center — Stanford, California, United States
• Yale University School of Medicine — New Haven, Connecticut, United States
• Georgetown University Medical Center — Washington D.C., District of Columbia, United States
• Howard University — Washington D.C., District of Columbia, United States
• Mayo Clinic — Jacksonville, Florida, United States
• Wein Center, Mount Sinai Medical Center — Miami, Florida, United States
• University of South Florida — Tampa, Florida, United States
• Byrd Institute — Tampa, Florida, United States
• Premier Research Institute — West Palm Beach, Florida, United States
• Emory University — Atlanta, Georgia, United States
• Northwestern University — Chicago, Illinois, United States
• Southern Illinois University — Springfield, Illinois, United States
• Indiana University School of Medicine — Indianapolis, Indiana, United States
• University of Kansas — Kansas City, Kansas, United States
• Lahey Clinic, Research Neurology — Burlington, Massachusetts, United States
• University of Michigan — Ann Arbor, Michigan, United States

Full record on ClinicalTrials.gov

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