Growth Hormone to Increase Immune Function in People With HIV

Completed · Phase 2

Conditions studied: HIV Infections

In brief

Growth hormone plays an important role in the development of the immune system. Studies suggest that growth hormone may promote growth of the thymus, a gland responsible for the production of important immune cells called T cells. Since these cells are lost during the course of HIV infection, it is possible that growth hormone treatment could help restore the immune system. This study will determine whether the administration of growth hormone can increase the size and function of the thymus and cause an increase in the number of new T cells in the blood of people infected with HIV. Study hypothesis: Growth hormone treatment will enhance T cell production in HIV infected adults.

Key facts

Study ID

NCT00071240

Run by

National Institute of Allergy and Infectious Diseases (NIAID)

People needed

22

Starts

2002-10-01

Expected to finish

2007-09-01

Last updated by the study team

2009-08-17

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• HIV infected
• CD4 count 400 cells/mm3 or less
• HIV viral load less than 1000 copies/ml for 1 year prior to study entry; in some cases, viral load up to 5000 copies/ml will be acceptable
• Taking at least 2 anti-HIV medications

You may not qualify if…

• Diabetes
• Cancer. Patients with some cases of Kaposi's sarcoma or skin cancer will not be excluded.
• Some (not all) forms of heart disease
• Carpal Tunnel Syndrome
• Pregnant or breastfeeding

Where it is running

• Gladstone Institute of Virology and Immunology — San Francisco, California, United States

Full record on ClinicalTrials.gov

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