ZD6474 Alone or in Combination With Paclitaxel and Carboplatin in Subjects With Previously Untreated Locally Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC)
Completed · Phase 2
Conditions studied: Carcinoma, Non-Small-Cell Lung
In brief
The purpose of the run-in phase of this study is to determine the appropriate and tolerable dose of ZD6474 (200mg or 300mg) to be administered in combination with paclitaxel and carboplatin in subjects with previously untreated locally advanced or metastatic NSCLC. This phase of the trial is closed to enrollment. The purpose of the randomized phase of this study is to determine the efficacy of ZD6474 alone versus that of ZD6474 in combination with paclitaxel and carboplatin versus that of paclitaxel and carboplatin alone in subjects with previously untreated locally advanced or metastatic NSCLC. This phase of the trial is closed to enrollment.
Key facts
- Study ID
- NCT00071188
- Run by
- Genzyme, a Sanofi Company
- Starts
- 2004-02-01
- Expected to finish
- 2007-10-01
- Last updated by the study team
- 2016-08-25
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Signed informed consent
- 18 years or older
- Histologically or cytologically confirmed locally advanced or metastatic NSCLC
- No prior chemotherapy/biological therapy/radiation therapy
- One or more measurable lesions
- Life expectancy more than 12 weeks
You may not qualify if…
- Brain metastases or spinal cord compression
- Currently active skin disease
- History of significant hemoptysis
- Abnormal blood chemistry
- Cardiac abnormalities
- Recent significant cardiac event
- Coexisting malignancies
Where it is running
- Research Site — Concord, California, United States
- Research Site — Los Angeles, California, United States
- Research Site — Chicago, Illinois, United States
- Research Site — Boston, Massachusetts, United States
- Research Site — St Louis, Missouri, United States
- Research Site — Providence, Rhode Island, United States
- Research Site — Nashville, Tennessee, United States
- Research Site — Austin, Texas, United States
- Research Site — Houston, Texas, United States
- Research Site — Lubbock, Texas, United States
- Research Site — Norfolk, Virginia, United States
- Research Site — Seattle, Washington, United States
- Research Site — Helsinki, Finland
- Research Site — Turku, Finland
- Research Site — Besançon, France
- Research Site — Lille, France
- Research Site — Strasbourg, France
- Research Site — Essen, Germany
- Research Site — Frankfurt, Germany
- Research Site — Mainz, Germany
- Research Site — Ulm, Germany
- Research Site — Pune, India
- Research Site — Milan, Italy
- Research Site — Orbassano, Italy
- Research Site — Cape Town, South Africa
Full record on ClinicalTrials.gov
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