Safety and Effectiveness of Two Blood Transfusion Strategies in Surgical Patients With Cardiovascular Disease

Completed · Phase 3

Conditions studied: Anemia, Hematologic Diseases, Cardiovascular Diseases, Heart Diseases, Myocardial Infarction, Thromboembolism, Pneumonia, Cerebrovascular Accident

In brief

The purpose of this study is to compare liberal red blood cell transfusion therapy with restrictive red blood cell transfusion therapy in surgical patients with cardiovascular disease or risk factors.

Key facts

Study ID

NCT00071032

Run by

Rutgers, The State University of New Jersey

People needed

2016

Starts

2003-07-01

Expected to finish

2009-05-01

Last updated by the study team

2020-11-16

Who can join

Age: 50 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Has undergone surgical repair for a hip fracture
• Has a postoperative Hgb level below 10 g/dL within three days of surgery
• Diagnosis of cardiovascular disease (e.g., coronary artery disease, congestive heart failure, stroke or transient ischemic attack, or peripheral vascular disease) or cardiovascular risk factors (e.g., diabetes mellitus, hypertension, hypercholesterolemia, tobacco use, or creatinine levels greater than 2.0 mg/dL)

You may not qualify if…

• Unable to walk prior to hip fracture
• Declines blood transfusions
• Suffered multiple traumas
• Pathologic fracture of the hip due to malignancy
• Clinically recognized acute myocardial infarction within the 30 days prior to study entry
• Previously participated in the trial and fractured the other hip
• Symptoms associated with anemia (e.g., ischemic chest pain) or actively bleeding at the time of randomization

Where it is running

• University Medicine & Dentistry of NJ — New Brunswick, New Jersey, United States

Full record on ClinicalTrials.gov

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