Creatine for the Treatment of Amyotrophic Lateral Sclerosis

Completed · Phase 2

Conditions studied: Amyotrophic Lateral Sclerosis

In brief

Creatine is a naturally occurring chemical involved in the production of energy in muscle. Abnormalities in creatine have been linked to the progression of degenerative neuromuscular diseases such as amyotrophic lateral sclerosis (ALS, or Lou Gehrig's Disease). This study will test whether taking creatine can improve the symptoms of ALS.

Key facts

Study ID

NCT00070993

Run by

National Center for Complementary and Integrative Health (NCCIH)

People needed

110

Starts

2002-12-01

Expected to finish

2006-05-01

Last updated by the study team

2006-08-04

Who can join

Age: 21 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of probable or definite ALS
• At least 5 of 10 testable upper extremity muscle groups (shoulder and elbow extensors/flexors and grip) of Medical Research Council (MRC) grade 4 or better
• At least 5 years from onset of symptoms

You may not qualify if…

• Requires tracheostomy ventilation
• History of renal disease

Where it is running

• California Pacific Medical Center — San Francisco, California, United States
• Rush-Presbyterian St. Luke's Medical Center — Chicago, Illinois, United States
• University of Kansas Medical Center — Kansas City, Kansas, United States
• University of New Mexico - Medical Center — Albuquerque, New Mexico, United States
• University of Texas Health and Science Center — San Antonio, Texas, United States
• University of Virginia Health System — Charlottesville, Virginia, United States

Full record on ClinicalTrials.gov

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