Functional Brain Imaging - Acupuncture and Osteoarthritis

Completed · Phase 2/Phase 3

Conditions studied: Osteoarthritis

In brief

The goal of this study is to use single photon emission computed tomography (SPECT) and functional magnetic resonance imaging (f-MRI) of the brain to study the response of both normal participants and participants with Osteoarthritis (OA) of the knee to acupuncture.

Key facts

Study ID

NCT00070824

Run by

National Center for Complementary and Integrative Health (NCCIH)

People needed

16

Starts

2004-01-01

Expected to finish

2007-04-01

Last updated by the study team

2007-09-10

Who can join

Age: 40 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Seen in an outpatient clinical setting
• Have active knee OA of >6 months including Kellgren x-ray changes >2 from an x-ray report <12 months old or new x-ray interpretation
• Moderate unilateral only pain (average >4/10 on a 0-10 likert scale) for more than 5 out of 7 days
• Have the capacity to understand the requirements of the study and complete the baseline studies in a reasonable time frame, as determined by the interviewer

You may not qualify if…

• Having had acupuncture before (must be acupuncture naïve)
• Any history of claustrophobia that could affect the subject's ability to tolerate the f-MRI study
• Hip or ankle disease by history or exam severe enough to cause pain >2/10 daily
• Bleeding disorder or current use of warfarin or heparin by patient history
• Other primary causes of chronic knee pain, per the referring physician, including chondromalacia patella, torn meniscus or ligament injury.

Where it is running

• Hospital of the University of Pennsylvania — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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