Carboplatin and Gemcitabine Combined With Celecoxib and/or Zileuton in Treating Patients With Advanced Non-Small Cell Lung Cancer
Completed · Phase 2
Conditions studied: Lung Cancer
In brief
RATIONALE: Drugs used in chemotherapy, such as carboplatin and gemcitabine, work in different ways to stop tumor cells from dividing so they stop growing or die. Celecoxib and zileuton may stop the growth of tumor cells by stopping blood flow to the tumor and may block the enzymes necessary for tumor cell growth. Combining chemotherapy with celecoxib and/or zileuton may kill more tumor cells. PURPOSE: Randomized phase II trial to study the effectiveness of combining celecoxib and/or zileuton with carboplatin and gemcitabine in treating patients who have advanced non-small cell lung cancer.
Key facts
- Study ID
- NCT00070486
- Run by
- Alliance for Clinical Trials in Oncology
- People needed
- 140
- Starts
- 2003-12-01
- Expected to finish
- 2011-05-01
- Last updated by the study team
- 2016-06-30
Who can join
Age: 18 and older, up to 120. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Rebecca and John Moores UCSD Cancer Center — La Jolla, California, United States
- Cedars-Sinai Comprehensive Cancer Center at Cedars-Sinai Medical Center — Los Angeles, California, United States
- Naval Medical Center - San Diego — San Diego, California, United States
- Veterans Affairs Medical Center - San Diego — San Diego, California, United States
- UCSF Comprehensive Cancer Center — San Francisco, California, United States
- Veterans Affairs Medical Center - San Francisco — San Francisco, California, United States
- CCOP - Christiana Care Health Services — Newark, Delaware, United States
- Lombardi Cancer Center at Georgetown University Medical Center — Washington D.C., District of Columbia, United States
- Walter Reed Army Medical Center — Washington D.C., District of Columbia, United States
- Veterans Affairs Medical Center - Washington, DC — Washington D.C., District of Columbia, United States
- Broward General Medical Center — Fort Lauderdale, Florida, United States
- Memorial Regional Cancer Center at Memorial Regional Hospital — Hollywood, Florida, United States
- CCOP - Mount Sinai Medical Center — Miami Beach, Florida, United States
- Palm Beach Cancer Institute — West Palm Beach, Florida, United States
- MBCCOP - University of Illinois at Chicago — Chicago, Illinois, United States
- Veterans Affairs Medical Center - Chicago (Westside Hospital) — Chicago, Illinois, United States
- University of Chicago Cancer Research Center — Chicago, Illinois, United States
- Louis A. Weiss Memorial Hospital — Chicago, Illinois, United States
- CCOP - Evanston — Evanston, Illinois, United States
- CCOP - Illinois Oncology Research Association — Peoria, Illinois, United States
- West Suburban Center for Cancer Care — River Forest, Illinois, United States
- Fort Wayne Medical Oncology and Hematology, Incorporated — Fort Wayne, Indiana, United States
- CCOP - Northern Indiana CR Consortium — South Bend, Indiana, United States
- Holden Comprehensive Cancer Center at University of Iowa — Iowa City, Iowa, United States
- Northeast Alabama Regional Medical Center — Anniston, Alabama, United States
Full record on ClinicalTrials.gov
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