Rituximab, Prednisone, Cyclophosphamide, Doxorubicin, Vincristine, and Yttrium Y 90 Ibritumomab Tiuxetan in Treating Patients With Previously Untreated Mantle Cell Lymphoma

Completed · Phase 2

Conditions studied: Lymphoma

In brief

RATIONALE: Monoclonal antibodies, such as rituximab and yttrium Y 90 ibritumomab tiuxetan, can locate cancer cells and either kill them or deliver radioactive cancer-killing substances to them without harming normal cells. Drugs used in chemotherapy, such as prednisone, cyclophosphamide, doxorubicin, and vincristine, use different ways to stop cancer cells from dividing so they stop growing or die. Combining monoclonal antibody therapy with chemotherapy may kill more cancer cells. PURPOSE: This phase II trial is studying how well giving rituximab and combination chemotherapy together with yttrium Y 90 ibritumomab tiuxetan works in treating patients with previously untreated mantle cell lymphoma.

Key facts

Study ID

NCT00070447

Run by

National Cancer Institute (NCI)

Starts

2003-11-01

Expected to finish

2006-06-01

Last updated by the study team

2014-01-28

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

• CCOP - Mayo Clinic Scottsdale Oncology Program — Scottsdale, Arizona, United States
• City of Hope Comprehensive Cancer Center — Duarte, California, United States
• Veterans Affairs Medical Center - Palo Alto — Palo Alto, California, United States
• Stanford Cancer Center at Stanford University Medical Center — Stanford, California, United States
• CCOP - Colorado Cancer Research Program, Incorporated — Denver, Colorado, United States
• CCOP - Christiana Care Health Services — Newark, Delaware, United States
• MBCCOP - Howard University Cancer Center — Washington D.C., District of Columbia, United States
• Veterans Affairs Medical Center - Gainesville — Gainesville, Florida, United States
• Veterans Affairs Medical Center - Miami — Miami, Florida, United States
• H. Lee Moffitt Cancer Center and Research Institute at University of South Florida — Tampa, Florida, United States
• Veterans Affairs Medical Center - Tampa (Haley) — Tampa, Florida, United States
• Winship Cancer Institute of Emory University — Atlanta, Georgia, United States
• Veterans Affairs Medical Center - Atlanta (Decatur) — Decatur, Georgia, United States
• Veterans Affairs Medical Center - Lakeside Chicago — Chicago, Illinois, United States
• Robert H. Lurie Comprehensive Cancer Center at Northwestern University — Chicago, Illinois, United States
• CCOP - Central Illinois — Decatur, Illinois, United States
• CCOP - Evanston — Evanston, Illinois, United States
• CCOP - Illinois Oncology Research Association — Peoria, Illinois, United States
• Swedish-American Regional Cancer Center — Rockford, Illinois, United States
• CCOP - Carle Cancer Center — Urbana, Illinois, United States
• Indiana University Cancer Center — Indianapolis, Indiana, United States
• Veterans Affairs Medical Center - Indianapolis (Roudebush) — Indianapolis, Indiana, United States
• CCOP - Northern Indiana CR Consortium — South Bend, Indiana, United States
• CCOP - Cedar Rapids Oncology Project — Cedar Rapids, Iowa, United States
• Comprehensive Cancer Center at University of Alabama at Birmingham — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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