Induction Chemotherapy Using Cyclophosphamide and Topotecan in Treating Patients Who Are Undergoing Autologous Peripheral Stem Cell Transplantation for Newly Diagnosed or Progressive Neuroblastoma
Completed · Phase 1
Conditions studied: Neuroblastoma
In brief
RATIONALE: Drugs used in chemotherapy, such as topotecan and cyclophosphamide, use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with autologous stem cell transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more tumor cells. PURPOSE: This phase I trial is studying the side effects of induction chemotherapy using cyclophosphamide and topotecan in treating patients who are undergoing surgery and autologous stem cell transplantation followed by radiation therapy for newly diagnosed or progressive neuroblastoma.
Key facts
- Study ID
- NCT00070200
- Run by
- Children's Oncology Group
- People needed
- 31
- Starts
- 2004-03-01
- Expected to finish
- 2013-12-01
- Last updated by the study team
- 2014-02-13
Who can join
Age: any, up to 30. Sex: any. Healthy volunteers: not accepted.
Where it is running
- UCSF Comprehensive Cancer Center — San Francisco, California, United States
- Children's Memorial Hospital - Chicago — Chicago, Illinois, United States
- St. Jude Children's Research Hospital — Memphis, Tennessee, United States
- Children's Hospital and Regional Medical Center - Seattle — Seattle, Washington, United States
- Mary Bridge Children's Hospital and Health Center - Tacoma — Tacoma, Washington, United States
- Westmead Hospital — Westmead, New South Wales, Australia
Full record on ClinicalTrials.gov
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